trophoblast glycoprotein (5T4 oncofetal trophoblast glycoprotein, 5T4 oncotrophoblast glycoprotein, 5T4 oncofetal antigen, M6P1, TPBG 5T4)

Structure: - contains 7 LRR repeats (leucine-rich repeats) Compartment: membrane Expression: - expressed by all types of trophoblasts as early as 9 weeks of development - specific for trophoblastic cells except for amniotic epithelium - in adult tissues, expression is limited to a few epithelial cell types Pathology: - overexpressed by a wide spectrum of cancers, including colorectal carcinoma, ovarian cancer, gastric cancer

General

glycoprotein membrane protein

Properties

SIZE: MW = 46 kD entity length = 420 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-31} serine-rich region {32-53} MOTIF: serine residue (SEVERAL) N-glycosylation site {N81} leucine-rich repeat SITE: 90-113 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 117-140 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N124} leucine-rich repeat SITE: 141-164 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 209-232 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 233-256 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 258-280 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N275} leucine-rich repeat SITE: 334-355 MOTIF: leucine residue (SEVERAL) transmembrane domain {356-376}

Database Correlations

OMIM 190920 UniProt Q13641 PFAM correlations

References

UniProt :accession Q13641