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TP53 gene mutation
Genetics:
- defects in TP53 are a cause of Li-Fraumeni syndrome
- TP53 is frequently mutated or inactivated in about 60% of cancers
- defects in TP53 are involved in
a) esophageal squamous cell carcinoma
b) nasopharyngeal carcinoma
c) head & neck squamous cell carcinoma
d) oral squamous cell carcinoma
e) lung cancer
f) choroid plexus papilloma
g) one form of hereditary adrenocortical carcinoma
h) Barrett metaplasia
Related
cellular tumor antigen p53; tumor suppressor p53, phosphoprotein p53; antigen NY-CO-13 (TP53, p53)
General
gene mutation testing; gene mutation analysis
References
Loinc