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Toxoplasma gondii IgG in serum (VIDAS TOXO IgG Avidity assay, VIDAS TOXO IgG II)
Indications:
- evaluation of Toxoplasmosis caused by Toxoplasma gondii
Clinical significance:
- positive association between Toxoplasma gondii IgG ELISA serointensity & frailty* [5]
* somewhat curious given the finding that wolves infected with Toxoplasma gondii are 46 times more likely to become pack leaders & 11 times more likely to start a new pack than uninfected animals (see Toxoplasma gondii)
Principle:
- VIDAS TOXO IgG Avidity assay tests IgG aviditiy for Toxoplasma gondii antigen(s)
- more recent infection produces IgG with less avidity than long-standing IgG
Related
Toxoplasma gondii
General
Toxoplasma IgG in serum
Toxoplasma gondii IgG Ab
Toxoplasma gondii antibody in serum
References
- FDA NEWS RELEASE: May 19, 2011
FDA clears first test for recent infection with toxoplasmosis parasite
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm255922.htm
- Mini Panel of 2 tests: Toxoplasma gondii Ab, IgM . Toxoplasma gondii Ab, IgG
Laboratory Test Directory ARUP: 50521
- Toxoplasma gondii Ab, IgG
Laboratory Test Directory ARUP: 50770
- Panel of 4 tests
Laboratory Test Directory ARUP: 50772
- Mohyuddin H, Laffon B, Teixeira JP et al
Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty.
J Gerontol A Biol Sci Med Sci. 2023 Nov 6:glad228
PMID: 37939652
https://academic.oup.com/biomedgerontology/advance-article/doi/10.1093/gerona/glad228/7334598