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Toxoplasma gondii IgG in serum (VIDAS TOXO IgG Avidity assay, VIDAS TOXO IgG II)

Indications: - evaluation of Toxoplasmosis caused by Toxoplasma gondii Clinical significance: - positive association between Toxoplasma gondii IgG ELISA serointensity & frailty* [5] * somewhat curious given the finding that wolves infected with Toxoplasma gondii are 46 times more likely to become pack leaders & 11 times more likely to start a new pack than uninfected animals (see Toxoplasma gondii) Principle: - VIDAS TOXO IgG Avidity assay tests IgG aviditiy for Toxoplasma gondii antigen(s) - more recent infection produces IgG with less avidity than long-standing IgG

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Toxoplasma gondii

General

Toxoplasma IgG in serum Toxoplasma gondii IgG Ab Toxoplasma gondii antibody in serum

References

  1. FDA NEWS RELEASE: May 19, 2011 FDA clears first test for recent infection with toxoplasmosis parasite http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm255922.htm
  2. Mini Panel of 2 tests: Toxoplasma gondii Ab, IgM . Toxoplasma gondii Ab, IgG Laboratory Test Directory ARUP: 50521
  3. Toxoplasma gondii Ab, IgG Laboratory Test Directory ARUP: 50770
  4. Panel of 4 tests Laboratory Test Directory ARUP: 50772
  5. Mohyuddin H, Laffon B, Teixeira JP et al Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty. J Gerontol A Biol Sci Med Sci. 2023 Nov 6:glad228 PMID: 37939652 https://academic.oup.com/biomedgerontology/advance-article/doi/10.1093/gerona/glad228/7334598