DNA topoisomerase 3-alpha; DNA topoisomerase III alpha (TOP3A, TOP3)

Function: - reduces the number of supercoils in a highly negatively supercoiled DNA - component of the RMI complex - ATP-independent breakage of single-stranded DNA, followed by passage & rejoining - directly interacts with BLM & RMI1 Structure: - belongs to the prokaryotic type I/III topoisomerase family - contains 1 Toprim domain Alternative splicing: named isoforms=2 Expression: - high expression is found in testis, heart, skeletal muscle & pancreas

General

phosphoprotein topoisomerase-3 zinc finger protein

Properties

SIZE: entity length = 1001 aa MW = 112 kD COMPARTMENT: cell nucleus MOTIF: Toprim {35-179} MOTIF: Ser phosphorylation site {S54} tyrosine residue {Y362} Zn finger C4-type SITE: 658-685 EFFECTOR-BOUND: Zn+2 Ser phosphorylation site {S771} 2 X 27 AA approximate repeats {812-923} MOTIF: consensus repeat {812-839} consensus repeat {896-923}

Database Correlations

OMIM 601243 UniProt Q13472 PFAM correlations Entrez Gene 7156 Kegg hsa:7156 ENZYME 5.99.1.2

References

UniProt :accession Q13472