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toll like receptor 11 (TLR11)

Function: - immunological-response genes are activated by recognition of peptides from pathogenic bacteria by TLR11. - cells that express TL11 respond to uropathogenic E coli but not to non-pathogenic bacterial strains Expression: - mouse TLR11 is expressed in: macrophages, liver, kidney & bladder epithelial cells, but not other cells

General

toll-like receptor

Properties

COMPARTMENT: plasma membrane MOTIF: ligand-binding site transmembrane domain

References

  1. Journal Watch 24(9):72, 2004
    1. Zhang D, Zhang G, Hayden MS, Greenblatt MB, Bussey C, Flavell RA, Ghosh S. A toll-like receptor that prevents infection by uropathogenic bacteria. Science. 2004 Mar 5;303(5663):1522-6. PMID: 15001781
    2. O'Neill LA. Immunology. After the toll rush. Science. 2004 Mar 5;303(5663):1481-2. No abstract available. PMID: 15001768