Toll-like receptor 1; Toll/interleukin-1 receptor-like protein; TIL; CD281 (TLR1, KIAA0012)

Function: 1) innate immune response to microbial agents 2) cooperates with TLR2 - modulates response to microbial constituents 3) acts via MyD88 & TRAF6 a) NF-kappa-B activation b) cytokine secretion c) inflammatory response 4) binds TLR2 via their respective extracellular domains 5) binds MyD88 via their respective TIR domains Structure: - belongs to the Toll-like receptor family - contains 8 LRR repeats (leucine-rich repeats) - contains 1 TIR domain Compartment: - cell membrane - cytoplasmic vesicle - phagosome, phagosome membrane Expression: - ubiquitous - expressed in spleen, ovary, peripheral blood leukocytes, thymus, small intestine

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein leucine-rich repeat-containing protein (LRRC) toll-like receptor

Properties

SIZE: entity length = 786 aa MW = 90 kD COMPARTMENT: cytoplasm cellular membrane MOTIF: signal sequence {1-24} N-glycosylation site {N51} leucine-rich repeat SITE: 68-91 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 93-113 MOTIF: leucine residue (SEVERAL) cysteine residue {C110} MODIFICATION: cysteine residue {C132} leucine-rich repeat SITE: 114-137 MOTIF: leucine residue (SEVERAL) cysteine residue {C132} MODIFICATION: cysteine residue {C110} N-glycosylation site {N137} leucine-rich repeat SITE: 139-164 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N163} cysteine residue {C223} MODIFICATION: cysteine residue {C230} cysteine residue {C230} MODIFICATION: cysteine residue {C223} bacterial lipopeptide interaction {313-316} N-glycosylation site {N330} cysteine residue {C343} MODIFICATION: cysteine residue {C368} cysteine residue {C368} MODIFICATION: cysteine residue {C343} leucine-rich repeat SITE: 371-395 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 397-423 MOTIF: leucine residue (SEVERAL) cysteine residue {C419} MODIFICATION: cysteine residue {C442} N-glycosylation site {N429} cysteine residue {C442} MODIFICATION: cysteine residue {C419} leucine-rich repeat SITE: 444-467 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 469-491 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N578} transmembrane domain {581-601} TIR domain {635-779}

Database Correlations

OMIM 601194 MORBIDMAP 601194 UniProt Q15399 PFAM correlations Entrez Gene 7096 Kegg hsa:7096