trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26, glycine-tryptophan protein of 182 kD, GW182 autoantigen, protein GW1, EMSY interactor protein, TNRC6A, CAGH26, KIAA1460, TNRC6)

Function: - binds to mRNA - role in structure/maintenance &/or stability of GW body structures - phosphorylated Structure: contains 1 RRM domain (RNA recognition motif) Compartment: - cytoplasm, P-body - in structures called GW bodies Alternative splicing: named isoforms=5 Pathology: - antibodies against TNRC6A are found in sera from patients with Sjoegren syndrome, ataxia & sensor neuropathy diseases that develop autoantibodies against protein of the GWB structure - autoantibodies were mapped to the GW-rich mid-part, the non-GW-rich region and the C-terminus of the protein.

General

phosphoprotein RNA-binding protein

Properties

SIZE: MW = 210 kD entity length = 1962 aa COMPARTMENT: cytoplasm MOTIF: coiled coil {7-54} glutamine-rich region {93-127} MOTIF: glutamine residue (SEVERAL) serine-rich region {192-365} MOTIF: serine residue (SEVERAL) RNP motif NAME: RNP motif SITE: 1781-1853 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif

References

UniProt :accession Q8NDV7