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troponin I, cardiac muscle; cardiac troponin I (TNNI3, TNNC1)

Function: - troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers Ca+2 sensitivity to striated muscle actomyosin ATPase activity - binds to actin & tropomyosin - interacts with TRIM63 Structure: belongs to the troponin I family Pathology: - defects in TNNI3 are the cause of: a) familial hypertrophic cardiomyopathy type 7 b) familial restrictive cardiomyopathy type 1 c) dilated cardiomyopathy type 2A

Related

troponin troponin-I in serum/plasma

General

troponin-I

Properties

SIZE: entity length = 210 aa MW = 24 kD MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S23} Ser phosphorylation site {S24} Involved in binding TNC {32-79} cysteine residue {80} cysteine residue {97} Involved in binding TNC and actin {129-149}

Database Correlations

OMIM correlations MORBIDMAP 191044 UniProt P19429 Pfam PF00992 Entrez Gene 7137 Kegg hsa:7137

References

  1. UniProt :accession P19429
  2. Familial hypertrophic cardiomyopathy mutation database http://www.angis.org.au/Databases/heart/heartbreak.html
  3. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=TNNI3