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tumor necrosis factor ligand superfamily member 14; Herpes virus entry mediator ligand; HVEM-L; CD258 (TNFSF14, HVEML, LIGHT, UNQ391/PRO726)
Function:
- cytokine that binds to TNFRSF3/LTBR
- binding to the decoy receptor TNFRSF6B modulates its effects
- activates NFKB, stimulates the proliferation of T-cells, & inhibits growth of the adenocarcinoma HT-29
- the soluble form of isoform 1 derives from the membrane form by proteolytic processing
Structure:
- homotrimer
- N-glycosylated
- belongs to the tumor necrosis factor family
Compartment:
- cell membrane; single-pass type 2 membrane protein
- soluble & membrane forms
- isoform 2: cytoplasm
Alternative splicing: named isoforms=2
Expression:
- predominantly expressed in the spleen
- also found in the brain
- weakly expressed in peripheral lymphoid tissues & in heart, placenta, liver, lung, appendix, & kidney,
- no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines
- up-regulated after T-cell activation
Pathology:
- acts as a receptor for Herpes simplex virus
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
tumor necrosis factor (TNF) family protein
Properties
SIZE: entity length = 240 aa
MW = 26 kD
COMPARTMENT: cytoplasm
MOTIF: transmembrane domain {38-58}
proteolytic site {82-83}
N-glycosylation site {N102}
cysteine residue {C154}
MODIFICATION: cysteine residue {C187}
cysteine residue {C187}
MODIFICATION: cysteine residue {C154}
Database Correlations
OMIM 604520
UniProt O43557
Pfam PF00229
Entrez Gene 8740
Kegg hsa:8740
References
- UniProt :accession O43557
- Entrez Gene :accession 8740