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CD253; tumor necrosis factor ligand superfamily member 10; apo-2 ligand; apo-2L; TNF-related apoptosis-inducing ligand; protein TRAIL (TNFSF10, APO2L, TRAIL)
Function:
- cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 & possibly also to TNFRSF11B/OPG
- induces apoptosis
- its activity may be modulated by binding to decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 & TNFRSF11B/OPG that cannot induce apoptosis
Cofactor: binds 1 Zn+2 per trimer
Structure:
- homotrimer
- belongs to the tumor necrosis factor family
Compartment:
- membrane; single-pass type 2 membrane protein (putative)
Expression:
- widespread; most predominant in spleen, lung & prostate
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
tumor necrosis factor (TNF) family protein
Properties
SIZE: entity length = 281 aa
MW = 33 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {18-38}
Zn+2-binding site
SITE: 230-230
References
- UniProt :accession P50591
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/TNFSF10ID42632ch3q26.html
Databases & Figures
OMIM 603598
UniProt P50591
Pfam PF00229
Entrez Gene 8743
Kegg hsa:8743
TRAIL -> caspase 8 -> bid -> smac/diablo -> IAP ...