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CD120b; tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor 2; TNF-R2; tumor necrosis factor receptor type II; p75; p80 TNF-alpha receptor; p75TNF receptor; TBPII; TBP-2 (TNFRSF1B, TNFBR, TNFR2)

Function: - receptor with high affinity for TNFSF2/TNF-alpha - approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha - the TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 & BIRC3 to TNFRSF1B/TNFR2 - mediates most of the metabolic effects of TNF-alpha - secreted isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity - binds to TRAF2 - phosphorylated; mainly on Ser & with a very low level on Thr - a soluble form (tumor necrosis factor-binding protein 2) is produced from the membrane form by proteolytic processing Structure: contains 4 TNFR-Cys repeats Compartment: - isoform 1: cell membrane - isoform 2: secreted - tumor necrosis factor-binding protein 2: secreted Alternative splicing: named isoforms=2 Pharmacology: - available under the name Enbrel (Immunex & Wyeth-Ayerst) - used to treat moderate to severe rheumatoid arthritis (RA). - Enbrel consist of the extracellular ligand-binding portion of TNFRSF1B linked to an immunoglobulin Fc chain - it binds to TNF-alpha & blocks its interactions with receptors

Related

tumor necrosis factor [TNF]-alpha receptor-associated factor (TRAF) tumor necrosis factor [TNF]-alpha; tumor necrosis factor ligand superfamily member 2; cachectin (TNF, TNFA, TNFSF2)

Specific

tumor necrosis factor-binding protein 2 (TNFBP2)

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein tumor necrosis factor [TNF] receptor family

Properties

SIZE: entity length = 461 aa MW = 48 kD COMPARTMENT: plasma membrane MOTIF: signal sequence {1-22} TNFR-Cys {39-76} MOTIF: cysteine residue {C40} MODIFICATION: cysteine residue {C53} cysteine residue {C53} MODIFICATION: cysteine residue {C40} cysteine residue {C54} MODIFICATION: cysteine residue {C67} cysteine residue {C57} MODIFICATION: cysteine residue {C75} cysteine residue {C67} MODIFICATION: cysteine residue {C54} cysteine residue {C75} MODIFICATION: cysteine residue {C57} TNFR-Cys {77-118} MOTIF: cysteine residue {C78} MODIFICATION: cysteine residue {C93} cysteine residue {C93} MODIFICATION: cysteine residue {C78} cysteine residue {C96} MODIFICATION: cysteine residue {C110} cysteine residue {C100} MODIFICATION: cysteine residue {C118} cysteine residue {C110} MODIFICATION: cysteine residue {C96} cysteine residue {C118} MODIFICATION: cysteine residue {C100} TNFR-Cys {119-162} MOTIF: cysteine residue {C120} MODIFICATION: cysteine residue {C126} cysteine residue {C126} MODIFICATION: cysteine residue {C120} cysteine residue {C134} MODIFICATION: cysteine residue {C143} cysteine residue {C137} MODIFICATION: cysteine residue {C161} cysteine residue {C143} MODIFICATION: cysteine residue {C134} cysteine residue {C161} MODIFICATION: cysteine residue {C137} TNFR-Cys {163-201} MOTIF: cysteine residue {C164} MODIFICATION: cysteine residue {C179} N-glycosylation site {N171} cysteine residue {C179} MODIFICATION: cysteine residue {C164} N-glycosylation site {N193} transmembrane domain {258-287}

Database Correlations

OMIM 191191 UniProt P20333 Pfam PF00020 Entrez Gene 7133 Kegg hsa:7133

References

  1. UniProt :accession P20333
  2. SeattleSNPs http://pga.gs.washington.edu/data/tnfrsf1b/
  3. NIEHS SNPs http://egp.gs.washington.edu/data/tnfrsf1b/
  4. Enbrel; Note: Clinical information on Enbrel http://www.enbrel.com/
  5. Taga T & Kishimoto T Cytokine receptors and signal transduction FASEB J 6:3387 1992 PMID: 1334470
  6. Nagata S, Golstein P. The Fas death factor. Science. 1995 Mar 10;267(5203):1449-56. Review. PMID: 7533326
  7. Entrez Gene :accession 7133