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tumor necrosis factor receptor superfamily member 10B; death receptor 5; TNF-related apoptosis-inducing ligand receptor 2; TRAIL receptor 2; TRAIL-R2; CD262 (TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9, UNQ160/PRO186)

Function: - receptor for the cytotoxic ligand TNFSF10/TRAIL - the adapter molecule FADD recruits caspase-8 to the activated receptor; the resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis - promotes the activation of NF- kappa-B - TRAILR1 & TRAILR2 mediate apoptosis - can interact with TRADD & RIP Structure: - homotrimer. - contains 1 death domain - contains 3 TNFR-cys repeats Compartment: membrane Alternative splicing: named isoforms=2; TRICK2A, TRICK2B Expression: - widely expressed in adult & fetal tissues - highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach & throughout the intestinal tract; - not detectable in brain - induced by the tumor suppressor p53 Pathology: - very highly expressed in tumor cell lines such as HeLa S3, K562, HL-60, SW480, A549 & G361; - defects in TNFRSF10B may be a cause of squamous cell carcinoma of the head & neck Note: - may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

Related

DR5 gene

Specific

Death Receptor Dr5 Topical

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen tumor necrosis factor [TNF] receptor family

Properties

SIZE: entity length = 440 aa MW = 48 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-55} TNFR-Cys {57-94} MOTIF: cysteine residue {C81} MODIFICATION: cysteine residue {C94} cysteine residue {C94} MODIFICATION: cysteine residue {C81} TNFR-Cys {97-137} MOTIF: cysteine residue {C97} MODIFICATION: cysteine residue {C113} cysteine residue {C113} MODIFICATION: cysteine residue {C97} cysteine residue {C116} MODIFICATION: cysteine residue {C129} cysteine residue {C119} MODIFICATION: cysteine residue {C137} cysteine residue {C129} MODIFICATION: cysteine residue {C116} cysteine residue {C137} MODIFICATION: cysteine residue {C119} TNFR-Cys {138-178} MOTIF: cysteine residue {C139} MODIFICATION: cysteine residue {C153} cysteine residue {C153} MODIFICATION: cysteine residue {C139} cysteine residue {C156} MODIFICATION: cysteine residue {C170} cysteine residue {C160} MODIFICATION: cysteine residue {C178} cysteine residue {C170} MODIFICATION: cysteine residue {C156} cysteine residue {C178} MODIFICATION: cysteine residue {C160} TAPE {192-206} transmembrane domain {211-231} glycine-rich region {250-253} death domain NAME: death domain SITE: 339-422

References

  1. UniProt :accession O14763
  2. Pan G et al An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 277:815-8, 1997 PMID: 9242610
  3. Wu GS et al KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene. Nature Genetics 17:141-3, 1997 PMID: 9326928
  4. Entrez Gene :accession 8795

Databases & Figures

OMIM correlations UniProt O14763 PFAM correlations Entrez Gene 8795 Kegg hsa:8795 TRAIL -> caspase 8 -> bid -> smac/diablo -> IAP ...