tumor necrosis factor [TNF] receptor family

Homology in cysteine-rich region of extracellular domain.

Specific

lymphotoxin alpha/beta receptor; tumor necrosis factor receptor superfamily member 3; lymphotoxin-beta receptor; tumor necrosis factor receptor 2-related protein; tumor necrosis factor C receptor (LTBR, D12S370, TNFCR, TNFRSF3) Shope fibroma virus T2 protein CD120a; TNF receptor-1A; tumor necrosis factor receptor superfamily member 1A; p60; TNF-R1; TNF-RI; TNFR-I; p55;; TBPI (TNFRSF1A, TNFAR, TNFR1) CD120b; tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor 2; TNF-R2; tumor necrosis factor receptor type II; p75; p80 TNF-alpha receptor; p75TNF receptor; TBPII; TBP-2 (TNFRSF1B, TNFBR, TNFR2) CD134; tumor necrosis factor receptor superfamily member 4; OX40L receptor; ACT35 antigen; TAX transcriptionally-activated glycoprotein 1 receptor (TNFRSF4, TXGP1L) CD40 [CDw40], TNF receptor family member 5 (TNFRSF5), Bp50 or B-cell activation protein CD40 CD95; Fas antigen; tumor necrosis factor receptor superfamily member 6; apo-1 antigen; apoptosis-mediating surface antigen FAS; FASLG receptor (FAS, APT1, FAS1, TNFRSF6) CD27, CD27L receptor, TNF receptor family, member 7 (TNFRSF7) or T-cell activation antigen T4 CD30; tumor necrosis factor receptor superfamily member 8; CD30L receptor; lymphocyte activation antigen CD30; KI-1 antigen (TNFRSF8, D1S166E) CD271; p75 NGFR; tumor necrosis factor receptor superfamily member 16; low-affinity nerve growth factor receptor; NGF receptor; Gp80-LNGFR; p75 ICD; low affinity neurotrophin receptor p75NTR (NGFR, TNFRSF16) TNF receptor family, member 22 (TNFRSF22) TNF receptor family, member 23 (TNFRSF23) tumor necrosis factor receptor superfamily member 10A; death receptor 4; TNF-related apoptosis-inducing ligand receptor 1; TRAIL receptor 1; TRAIL-R1; CD261 (TNFRSF10A, APO2, DR4, TRAILR1) tumor necrosis factor receptor superfamily member 10B; death receptor 5; TNF-related apoptosis-inducing ligand receptor 2; TRAIL receptor 2; TRAIL-R2; CD262 (TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9, UNQ160/PRO186) tumor necrosis factor receptor superfamily member 10C; decoy receptor 1; DcR1; Decoy TRAIL receptor without death domain; TNF-related apoptosis-inducing ligand receptor 3; TRAIL receptor 3; TRAIL-R3; trail receptor without an intracellular domain; lymphocyte inhibitor of TRAIL; antagonist decoy receptor for TRAIL/apo-2L; CD263 (TNFRSF10C DCR1 LIT TRAILR3 TRID UNQ321/PRO366) tumor necrosis factor receptor superfamily member 10D; decoy receptor 2; DcR2; TNF-related apoptosis-inducing ligand receptor 4; TRAIL receptor 4; TRAIL-R4; TRAIL receptor with a truncated death domain; CD264 (TNFRSF10D, DCR2, TRAILR4, TRUNDD, UNQ251/PRO288) tumor necrosis factor receptor superfamily member 11A; receptor activator of NF-KB; osteoclast differentiation factor receptor; ODFR; CD265 (TNFRSF11A, RANK) tumor necrosis factor receptor superfamily member 11B; osteoprotegerin; osteoclastogenesis inhibitory factor (TNFRSF11B OCIF OPG) tumor necrosis factor receptor superfamily member 12A; fibroblast growth factor-inducible immediate-early response protein 14; FGF-inducible 14; Tweak-receptor; TweakR; CD266 (TNFRSF12A, FN14) tumor necrosis factor receptor superfamily member 13B; transmembrane activator & CAML interactor; CD267 (TNFRSF13B, TACI) tumor necrosis factor receptor superfamily member 13C; B cell-activating factor receptor; BAFF receptor; BAFF-R; BLyS receptor 3; CD268 (TNFRSF13C, BAFFR, BR3) tumor necrosis factor receptor superfamily member 14; Herpesvirus entry mediator A; tumor necrosis factor receptor-like 2; TR2 (TNFRSF14, HVEA, HVEM, UNQ329/PRO509) tumor necrosis factor receptor superfamily member 17; CD269; B-cell maturation protein (TNFRSF17, BCM, BCMA, CD269) tumor necrosis factor receptor superfamily member 18; glucocorticoid-induced TNFR-related protein; activation-inducible TNFR family receptor (TNFRSF18, AITR, GITR, UNQ319/PRO364) tumor necrosis factor receptor superfamily member 19; Toxicity & JNK inducer; TRADE (TNFRSF19, TAJ, TROY, UNQ1888/PRO4333) tumor necrosis factor receptor superfamily member 19L; receptor expressed in lymphoid tissues (RELT, TNFRSF19L) tumor necrosis factor receptor superfamily member 21; TNFR-related death receptor 6; Death receptor 6 (TNFRSF21 DR6 UNQ437/PRO868) tumor necrosis factor receptor superfamily member 25; WSL-1 protein; apoptosis-mediating receptor DR3; apoptosis-mediating receptor TRAMP; Death domain receptor 3; WSL protein; apoptosis-inducing receptor AIR; apo-3; lymphocyte-associated receptor of death; LARD (TNFRSF25, APO3, DDR3, DR3, TNFRSF12, WSL, WSL1, UNQ455/PRO779) tumor necrosis factor receptor superfamily member 27; X-linked ectodysplasin-A2 receptor; EDA-A2 receptor (EDA2R, TNFRSF27, XEDAR, UNQ2448/PRO5727/PRO34080) tumor necrosis factor receptor superfamily member 6B; decoy receptor for Fas ligand; decoy receptor 3; DcR3; M68 (TNFRSF6B, DCR3, TR6, UNQ186/PRO212) CD137; tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor; T-cell antigen 4-1BB homolog; T-cell antigen ILA; CDw137 (TNFRSF9, CD137, ILA) tumor necrosis factor receptor superfamily member EDAR; Anhidrotic ectodysplasin receptor 1; ectodysplasin-A receptor; EDA-A1 receptor; ectodermal dysplasia receptor; downless homolog (EDAR, DL) vaccinia virus protein A53; SalF19 receptor

General

cell surface receptor metabotropic receptor

Properties

COMPARTMENT: plasma membrane MOTIF: ligand-binding site cysteine-rich region MOTIF: cysteine residue {X+0} MODIFICATION: cysteine residue {X+14} cysteine residue {X+14} MODIFICATION: cysteine residue {X+0} cysteine residue {X+16} MODIFICATION: cysteine residue {X+29} cysteine residue {X+19} MODIFICATION: cysteine residue {X+34} cysteine residue {X+29} MODIFICATION: cysteine residue {X+16} cysteine residue {X+34} MODIFICATION: cysteine residue {X+19} transmembrane domain

References

- Smith CA, Davis T, Anderson D, Solam L, Beckmann MP, Jerzy R, Dower SK, Cosman D, Goodwin RG. A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins. Science. 1990 May 25;248(4958):1019-23. PMID: 2160731