transmembrane protease, serine 11A (epidermal type-2 transmembrane serine protease, airway trypsin-like protease 1, esophageal cancer-susceptibility gene 1 protein, TMPRSS11A, ECRG1, HATL1, HESP)

Function: - probable serine protease - may play a role in cellular senescence - overexpression inhibits cell growth & induces G1 cell cycle arrest - may interact with ZBTB17 Structure: - belongs to the peptidase S1 family - contains 1 peptidase S1 domain - contains 1 SEA domain Compartment: membrane (putative) Alternative splicing: named isoforms=2 Expression: - expressed in esophagus, liver, colon & lung Pathology: down-regulated in esophageal cancers

Properties

SIZE: entity length = 421 aa MW = 48 kD COMPARTMENT: cellular membrane MOTIF: transmembrane domain {19-39} SEA domain {45-167} MOTIF: N-glycosylation site {N156} active site MOTIF: serine residue S1 domain {190-420} MOTIF: cysteine residue {C215} MODIFICATION: cysteine residue {C231} histidine residue {H230} cysteine residue {C231} MODIFICATION: cysteine residue {C215} aspartate residue {D275} N-glycosylation site {N306} cysteine residue {C340} MODIFICATION: cysteine residue {C356} cysteine residue {C356} MODIFICATION: cysteine residue {C340} cysteine residue {C367} MODIFICATION: cysteine residue {C396} serine residue {S371} cysteine residue {C396} MODIFICATION: cysteine residue {C367}

Database Correlations

UniProt Q6ZMR5 PFAM correlations

References

UniProt :accession Q6ZMR5