thymopoietin gamma; lamina-associated polypeptide 2, isoform gamma; thymopoietin, isoform gamma; TP gamma; thymopoietin-related peptide isoform gamma; TPRP isoform gamma; contains: thymopoietin; TP; splenin; TP5 (TMPO, LAP2)

Function: - may help direct assembly of the nuclear lamina & thus help maintain the structural organization of the nuclear envelope - possible receptor for attachment of lamin filaments to the inner nuclear membrane - may be involved in the control of initiation of DNA replication through its interaction with NAKAP95 - TP & TP5 may play a role in T-cell development & function - TP5 is an immunomodulating pentapeptide - mitosis-specific phosphorylation specifically abolishes its binding to lamin B & chromosomes (putative) - interacts with LMNB1, LMNB2, BANF1, AKAP8L, GMCL & chromosomes (putative) Structure: - as two structurally independent, non-interacting domains: - LEM-like (also called LAP2-N or LEM-D) - LEM-like binds DNA - LEM (also called LAP2-C or LEM-B) - LEM interacts with BANF1 - belongs to the LEM family - contains 1 LEM domain - contains 1 LEM-like domain - contains sequence for putative hydrophobic membrane spanning domain from exon 8 Compartment: - nuclear inner membrane - single-pass type 2 membrane protein - tightly associated with the nuclear lamina Alternative splicing: - named isoforms=3; alpha, beta, gamma - additional isoforms seem to exist Expression: - expressed in many tissues - most abundant in adult thymus & fetal liver Pharmacology: - TP5 is available under the names Timunox (Cilag), Sintomodulina (Italofarmaco) & Mepentil (Recordati) - used in treatment of primary & secondary immune deficiencies, autoimmunity, infections & cancer

Properties

GENERAL: thymopoietin RELATED: TP5 LAP2 protein splenin SIZE: entity length = 454 aa MW = 51 kD COMPARTMENT: cell nucleus FORM: thymopoietin gamma MOTIF: Nucleoplasmic {2-410} MOTIF: LEM-like {5-48} Linker {49-108} Thr phosphorylation site {T57} Ser phosphorylation site {S66} Ser phosphorylation site {S67} Thr phosphorylation site {T74} Ser phosphorylation site {S79} Thr phosphorylation site {T96} Thr phosphorylation site {T99} LEM domain {109-153} Thr phosphorylation site {T137} binding site SITE: 138-243 FOR-BINDING-OF: A-kinase anchor protein 8-like Ser phosphorylation site {S156} Ser phosphorylation site {S159} Thr phosphorylation site {T160} Thr phosphorylation site {T164} Ser phosphorylation site {S177} Ser phosphorylation site {S180} Ser phosphorylation site {S184} Thr phosphorylation site {T208} Thr phosphorylation site {T211} Ser phosphorylation site {S292} Binds lamins B {299-371} binding site SITE: 300-374 FOR-BINDING-OF: A-kinase anchor protein 8-like Ser phosphorylation site {S306} Ser phosphorylation site {S315} Ser phosphorylation site {S354} Thr phosphorylation site {T355} Ser phosphorylation site {S362} Ser phosphorylation site {S378} Ser phosphorylation site {S385} transmembrane domain {411-434}

Database Correlations

OMIM 188380 MORBIDMAP 188380 UniProt P42167 PFAM correlations Entrez Gene 7112 Kegg hsa:7112

References

UniProt :accession P42167