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transmembrane gamma-carboxyglutamic acid protein 1; proline-rich gamma-carboxyglutamic acid protein 1; proline-rich Gla protein 1 (PRRG1, PRGP1, TMG1)
Function:
- Gla residues are produced after subsequent post-translational modifications of Glu by vitamin K-dependent gamma-carboxylase
Structure:
- contains 1 Gla (gamma-carboxy-glutamate) domain
Compartment: -membrane; single-pass type 1 membrane protein (putative)
Expression:
- highly expressed in the spinal cord
General
proline-rich gamma-carboxyglutamic acid protein
Properties
SIZE: entity length = 218 aa
MW = 25 kD
COMPARTMENT: cellular membrane
MOTIF: Gla {21-66}
MOTIF: cysteine residue {C37}
MODIFICATION: cysteine residue {C42}
cysteine residue {C42}
MODIFICATION: cysteine residue {C37}
transmembrane domain {84-106}
proline-rich region
SITE: 131-135
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 604428
UniProt O14668
Pfam PF00594
Entrez Gene 5638
Kegg hsa:5638
References
UniProt :accession O14668