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tomoregulin-1 (transmembrane protein with EGF-like & one follistatin-like domain, TR-1, H7365, TMEFF1, C9orf2)
Function:
1) may inhibit NODAL & BMP signaling during neural patterning
2) may be a tumor suppressor in brain cancers
3) may interact with ST14
Structure:
- belongs to the tomoregulin family
- contains 1 EGF-like domain
- contains 2 Kazal-like domains
Compartment: cell membrane
Alternative splicing: named isoforms=2
Expression:
- expressed predominantly in brain
- lower levels in heart, placenta & skeletal muscle
Pathology:
- down-regulated in brain tumors as compared to control brain tissues
General
membrane protein
Properties
SIZE: MW = 41 kD
entity length = 380 aa
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-39}
glycine-rich region {45-52}
Kazal-type serine protease inhibitor domain {99-143}
MOTIF: cysteine residue {X+0}
MODIFICATION: cysteine residue {X+X4}
cysteine residue {X+X1}
MODIFICATION: cysteine residue {X+X3}
cysteine residue {X+X2}
MODIFICATION: cysteine residue {X+X5}
cysteine residue {X+X3}
MODIFICATION: cysteine residue {X+X1}
cysteine residue {X+X4}
MODIFICATION: cysteine residue {X+0}
cysteine residue {X+X5}
MODIFICATION: cysteine residue {X+X2}
FOR-BINDING-OF: serine protease
Kazal-type serine protease inhibitor domain {190-235}
MOTIF: cysteine residue {X+0}
MODIFICATION: cysteine residue {X+X4}
cysteine residue {X+X1}
MODIFICATION: cysteine residue {X+X3}
cysteine residue {X+X2}
MODIFICATION: cysteine residue {X+X5}
cysteine residue {X+X3}
MODIFICATION: cysteine residue {X+X1}
cysteine residue {X+X4}
MODIFICATION: cysteine residue {X+0}
cysteine residue {X+X5}
MODIFICATION: cysteine residue {X+X2}
FOR-BINDING-OF: serine protease
EGF domain {271-311}
MOTIF: cysteine residue {C275}
MODIFICATION: cysteine residue {C288}
cysteine residue {C283}
MODIFICATION: cysteine residue {C299}
cysteine residue {C288}
MODIFICATION: cysteine residue {C275}
cysteine residue {C299}
MODIFICATION: cysteine residue {C283}
cysteine residue {C301}
MODIFICATION: cysteine residue {C310}
cysteine residue {C310}
MODIFICATION: cysteine residue {C301}
transmembrane domain {331-351}
Database Correlations
OMIM 603421
UniProt Q8IYR6
PFAM correlations
References
UniProt :accession Q8IYR6