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transmembrane channel-like protein 2; transmembrane cochlear-expressed protein 2 (TMC2, C20orf145, UNQ907/PRO1928)
Function:
- normal function of cochlear hair cells
Structure: belongs to the TMC family
Compartment: membrane (putative)
Alternative splicing: named isoforms=3
Expression: expressed in fetal cochlea
General
transmembrane 6 protein
Properties
SIZE: entity length = 906 aa
MW = 103 kD
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-263}
MOTIF: lysine-rich region {6-242}
MOTIF: lysine residue (SEVERAL)
transmembrane domain {264-284}
exoplasmic loop {285-336}
transmembrane domain {337-357}
cytoplasmic loop {358-431}
transmembrane domain {432-452}
exoplasmic loop {453-508}
transmembrane domain {509-529}
cytoplasmic loop {530-693}
transmembrane domain {694-714}
exoplasmic loop {715-750}
transmembrane domain {751-771}
cytoplasmic domain {772-906}
Database Correlations
OMIM 606707
UniProt Q8TDI7
Pfam PF07810
Entrez Gene 117532
Kegg hsa:117532
References
UniProt :accession Q8TDI7