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transketolase 2 (transketolase-like 1, transketolase related protein, TKTL1, TKR, TKT2)
Function:
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
D-ribose 5-phosphate + D-xylulose 5-phosphate
Cofactor:
- binds 1 Ca+2 per subunit (putative)
- binds 1 thiamine pyrophosphate per subunit
Structure:
- homodimer (putative)
- belongs to the transketolase family
Compartment:
- cytoplasm, nucleus
- predominantly cytoplasmic & to a lesser extent nuclear
Alternative splicing:
- named isoforms=3
- additional isoforms seem to exist
Expression:
- expressed in fetal & adult heart, brain, lung, liver, & kidney, & in adult placenta, skeletal muscle & pancreas
Pathology:
- up-regulated in various epithelial tumors
- implicated in the genetic predisposition to Wernicke-Korsakoff syndrome
- strong TKTL1 protein expression has been correlated with aerobic glycolysis; Warburg effect & with cells which are affected by chronic complications of diabetic patients
- in colon carcinoma & urothelial carcinoma, expression (at protein level) is correlated with invasiveness of tumors & poor survival
Related
hexose monophosphate shunt, pentose phosphate pathway or phosphogluconate shunt
transketolase 2 (transketolase-like 1, transketolase related protein, TKTL1, TKR, TKT2)
General
Ca+2 binding protein
transketolase family protein
Properties
MOTIF: active site
Ca+2-binding site
Database Correlations
OMIM correlations
UniProt P51854
PFAM correlations
Entrez Gene 8277
ENZYME 2.2.1.1
References
UniProt :accession P51854