Contents

Search

tissue transglutaminase IgA in serum

Indications: - evaluation of celiac disease * titers >= 10X upper limit of normal diagnostic of celiac disease [9,10] * rule out celiac disease prior to diagnosis of irritable bowel syndrome [8] Clinical significance: - celiac disease is precipitated by ingestion of the protein gliadin, a component of wheat gluten - gliadin initiates mucosal damage which involves an immunological process in individuals with a genetic predisposition - IgA antibodies against gliadin & endomysium, a structure of smooth muscle connective tissue are found in patients with celiac disease - tissue transglutaminase is the endomysial autoantigen - gliadin is a preferred substrate for tissue transglutaminase

Related

anti-tissue transglutaminase IgA autoantibody

General

tissue transglutaminase antibody in serum

References

  1. Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO, Schuppan D. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med. 1997 Jul;3(7):797-801. PMID: 9212111
  2. Dieterich W, Laag E, Schopper H, Volta U, Ferguson A, Gillett H, Riecken EO, Schuppan D. Autoantibodies to tissue transglutaminase as predictors of celiac disease. Gastroenterology. 1998 Dec;115(6):1317-21 PMID: 9834256
  3. Sulkanen S, Halttunen T, Laurila K, Kolho KL, Korponay-Szabo IR, Sarnesto A, Savilahti E, Collin P, Maki M. Tissue transglutaminase autoantibody enzyme-linked immunosorbent assay in detecting celiac disease. Gastroenterology. 1998 Dec;115(6):1322-8. PMID: 9834257
  4. Blackwell PJ, Hill PG, Holmes GK. Autoantibodies to human tissue transglutaminase: superior predictors of coeliac disease. Scand J Gastroenterol. 2002 Nov;37(11):1282-5. PMID: 12465726
  5. Medical Knowledge Self Assessment Program (MKSAP) 15, American College of Physicians, Philadelphia 2009
  6. Tissue Transglutaminase (tTG) Ab, IgA Laboratory Test Directory ARUP: 50734
  7. Tissue Transglutaminase (tTG) Ab, IgA Laboratory Test Directory ARUP: 97709
  8. NEJM Knowledge+ Gastroenterology
  9. Shiha MG et al. Accuracy of the no-biopsy approach for the diagnosis of celiac disease in adults: A systematic review and meta-analysis. Gastroenterology 2024 Apr; 166:620 PMID: 38176661 Free article https://www.gastrojournal.org/article/S0016-5085(23)05688-3/fulltext
  10. Penny HA et al. Accuracy of a no-biopsy approach for the diagnosis of coeliac disease across different adult cohorts. Gut 2021 May; 70:876. PMID: 33139268 PMCID: PMC8040155 Free PMC article https://gut.bmj.com/content/70/5/876