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transcription intermediary factor 1-alpha; TIF1-alpha; RING finger protein 82; tripartite motif-containing protein 24 (TRIM24, RNF82, TIF1, TIF1A)
Function:
- interacts selectively in vitro with the AF2-activating domain of the estrogen receptors
- association with DNA-bound estrogen receptors requires the presence of estradiol
- phosphorylated upon DNA damage, probably by ATM or ATR
- interacts with CBX1 & CBX3 (putative)
- interacts with NR3C2
Structure:
- contains 2 B box-type Zn+2 fingers
- contains 1 bromo domain
- contains 1 PHD-type Zn+2 finger
- contains 1 RING-type Zn+2 finger
Compartment: nucleus (putative)
Alternative splicing: named isoforms=2; long, short
Pathology:
- defects in TRIM24 are a cause of thyroid papillary carcinoma
- translocation t(7;10)(q32;q11) with RET; translocation generates the TIF1/RET (PTC6) oncogene
General
DNA-binding protein
phosphoprotein
ring finger protein
Properties
SIZE: entity length = 1050 aa
MW = 117 kD
COMPARTMENT: cell nucleus
MOTIF: alanine-rich region {9-15}
MOTIF: alanine residue (SEVERAL)
RING-finger {56-82}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
zinc finger B box
SITE: 158-211
EFFECTOR-BOUND: Zn+2
zinc finger B box
SITE: 218-259
EFFECTOR-BOUND: Zn+2
coiled coil {289-359}
MOTIF: glutamine-rich region {344-347}
MOTIF: glutamine residue (SEVERAL)
breakpoint {476-477}
Ser phosphorylation site {S660}
Ser phosphorylation site {S667}
Ser phosphorylation site {S687}
Nuclear receptor binding site (NRBS) {754-779}
MOTIF: Ser phosphorylation site {S768}
Ser phosphorylation site {S808}
Ser phosphorylation site {S811}
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 826-873
EFFECTOR-BOUND: Zn+2
nuclear translocation signal {891-907}
bromodomain {932-987}
Ser phosphorylation site {S1019}
Ser phosphorylation site {S1025}
Ser phosphorylation site {S1028}
Database Correlations
OMIM correlations
UniProt O15164
PFAM correlations
Entrez Gene 8805
Kegg hsa:8805
References
- UniProt :accession O15164
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/TRIM24ID504ch7q34.html