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Krueppel-like factor 10; EGR-alpha; transforming growth factor-beta-inducible early growth response protein 1; TGFB-inducible early growth response protein 1; TIEG-1 (KLF10, TIEG, TIEG1)
Function:
- transcriptional repressor involved in the regulation of cell growth
- inhibits cell growth
- binds to the consensus sequence 5'-GGTGTG-3'
- ubiquitinated; mediated by SIAH1 & leading to its subsequent proteasomal degradation (probable)
Structure:
- belongs to the Sp1 C2H2-type Zn+2-finger protein family
- contains 3 C2H2-type Zn+2 fingers
Compartment: nucleus
Expression: induced by TGFB1
General
Krueppel-like factor
phosphoprotein
transcriptional silencer (transcriptional repressor)
Properties
SIZE: entity length = 480 aa
MW = 53 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S249}
Zn finger C2H2-type
SITE: 369-393
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 399-423
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 429-451
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 601878
UniProt Q13118
Entrez Gene 7071
Kegg hsa:7071
References
UniProt :accession Q13118