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TICORA study
Randomized trial.
110 outpatients with rheumatoid arthritis of < 5 years duration
intensive treatment (increasing dose of DMARDs + joint injections) vs routine therapy (DMARDs)
Outcomes assessed at 19 months
Results:
- intensive treatment resulted in decreased mean disease activity score.
- no difference in cost
General
clinical trial
References
Journal Watch 24(17):137-38, 2004
Grigor C, Capell H, Stirling A, McMahon AD, Lock P, Vallance R,
Kincaid W, Porter D.
Effect of a treatment strategy of tight control for rheumatoid
arthritis (the TICORA study): a single-blind randomised
controlled trial.
Lancet. 2004 Jul 17;364(9430):263-9.
PMID: 15262104