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ticarcillin clavulanate (Timentin)
Tradename: Timentin.
Indications:
- bacterial infections due to susceptible organisms
- skin or soft tissue infection
- diabetic foot infection
- intra-abdominal infection
- diverticulitis
- infectious arthritis, osteomyeltitis [3]
- empiric treatment of febrile neutropenia
- empiric treatment for fever of unknown origin
- pneumonia [3]
Contraindications:
pregnancy-category B
safety in lactation ?
Dosage: 3.1 g IV every 4-6 hours.
Pharmacokinetics: elimination: kidney.
Dosage adjustment in renal failure:
creatinine clearance dosage
> 50-90 mL/min 3.1 g every 4 hours
10-50 mL/min 2.0 g every 4-8 hours
< 10 mL/min* 2.0 g every 12 hours
* extra 3.1 g after hemodialysis
Antimicrobial activity:
Gram positive
- Streptococcus
- Streptococcus group A
- Streptococcus group B
- Streptococcus group C
- Streptococcus group G
- Streptococcus pneumonia
- Streptococcus viridans, milleri
- Enterococcus faecalis (+/-)
- Enterococcus faecium (+/-)
- Staphylococcus aureus (MSSA)
- Staphylococcus epidermidis (+/-)
- Listeria monocytogenes
Gram negative
- Neisseria gonorrhoeae
- Neisseria meningitidis
- Moraxella catarrhalis
- Haemophilus influenzae
- Escherichia coli
- Klebsiella species
- Enterobacter species
- Serratia species
- Salmonella species
- Proteus mirabilis
- Proteus vulgaris
- Providencia species
- Morganella species
- Citrobacter species
- Aeromonas species
- Acinetobacter species
- Pseudomonas aeruginosa
- Xanthomonas maltophilia
- Yersinia enterocolitica
- Pasteurella multocida
Anaerobes
- Bacteroides fragilis
- Bacteroides melaninogenicus
- Clostridium species
- Peptostreptococcus species
Laboratory:
- ticarcillin clavulanate in serum/plasma
General
beta-lactam/beta-lactamase inhibitor
Database Correlations
PUBCHEM cid=104960
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996.
- Department of Veterans Affairs, VA National Formulary
- Deprecated Reference
Components
clavulanate (clavulanic acid)
ticarcillin (Ticar)