Search
ticarcillin (Ticar)
Tradename: Ticar. 4th generation penicillin.
Indications:
- bacterial infections due to susceptible organisms
- anaerobic infection
- abscess
- brain abscess
- pulmonary abscess
- pelvic abscess
- parapneumonic effusion
- chronic suppurative otitis media
- intra-abdominal infection
- cholangitis
- urogenital infection
- urinary tract infection
- salpingitis
- pelvic inflammatory disease
- skin or soft tissue infection
- infectious arthritis, osteomyeltitis [4]
Dosage: 3-4 g IV/IM every 3-6 hours.
Pediatrics: 200-300 mg/kg/day divided every 4-6 h.
Dosage adjustment in renal failure:
creatinine clearance dosage
> 50-90 mL/min 1-2 g every 4 hours
10-50 mL/min* 1-2 g every 8 hours
< 10 mL/min# 1-2 g every 12 hours
* same dose for continuous arteriovenous hemofiltration
# extra 3 g after hemodialysis
Pharmacokinetics:
-> elimination 1/2life 1.2 hours (13 hours ESRD)
Antimicrobial activity:
Gram positive
- Streptococcus
- Streptococcus group A
- Streptococcus group B
- Streptococcus group C
- Streptococcus group G
- Streptococcus pneumonia
- Streptococcus viridans, milleri
- Enterococcus faecalis (+/-)
- Enterococcus faecium (+/-)
- Staphylococcus epidermidis (+/-)
- Listeria monocytogenes
Gram negative
- Neisseria gonorrhoeae
- Neisseria meningitidis
- Haemophilus influenzae (+/-)
- Escherichia coli (+/-)
- Enterobacter species
- Serratia species
- Salmonella species
- Shigella species
- Proteus mirabilis
- Proteus vulgaris
- Providencia species
- Morganella species
- Morganella morganii [4]
- Citrobacter species
- Aeromonas species
- Pseudomonas aeruginosa
- Yersinia enterocolitica (+/-)
- Pasteurella multocida
- Klebsiella penumoniae [4]
Anaerobes
- Bacteroides fragilis (+/-)
- Bacteroides melaninogenicus
- Clostridium species
- Peptostreptococcus species
Adverse effects:
1) hypersensitivity
2) hepatotoxicity
3) electrolyte & acid-base disturbances
4) reversible granulocytopenia
5) neurotoxicity
Drug interactions:
- probenecid delays renal secretion of ticarcillin
Laboratory:
1) specimen: serum, plasma (heparin, EDTA)
2) methods: MB, HPLC
Interactions
drug interactions
General
4th generation penicillin (extended-spectrum)
Properties
MISC-INFO: elimination route KIDNEY
LIVER
1/2life 1.2 HOURS
protein-binding 45-65%
elimination by hemodialysis +/-
pregnancy-category B
safety in lactation ?
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Sanford Guide to antimicrobial therapy 1997
- Clinical Guide to Laboratory Tests, NW Tietz (ed) 3rd ed,
WB Saunders, Philadelpha 1995
- Deprecated Reference
Component-of
ticarcillin clavulanate (Timentin)