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thyrotropin-releasing hormone; thyroliberin; protirelin (TRH)
Function:
1) induces release of thyroid-stimulating hormone from the anterior pituitary
2) induces release of prolactin from the pituitary
Compartment:
- secreted from hypothalamus into hypophyseal portal system
Expression:
- produced by thyrotropes in the hypothalamus, near the paraventricular nucleus
- produced by gastrointestinal system
- produced by pancreatic islets
Pharmacology: see Relefact
Related
thyroid-stimulating hormone (TSH) or thyrotropin
thyrotropin-releasing hormone receptor; TRH-R; thyroliberin receptor (TRHR)
TRH stimulation test
Specific
Relefact (thyrotropin-releasing hormone, TRH, Thypinone)
General
pituitary hormone-releasing hormone; hypothalamic hormone
Properties
COMPARTMENT: extracellular compartment
MISC-INFO: 1/2life 5 MIN
Database Correlations
OMIM 613879
UniProt P20396
Pfam PF05438
Entrez Gene 7200
Kegg hsa:7200
References
- Gkonos et al Mol Endocrinol 1989 Dec;3(12):2101-9
- Wikipedia, Thyrotropin-releasing hormone entry
http://en.wikipedia.org/wiki/Thyrotropin_releasing_hormone
- UniProt :accession P20396