thyrostimulin

Function: - activates the TSH receptor Structure: - glycoprotein hormone hormone consisting of 2 new glycoprotein hormone subunits

General

multisubunit protein secreted protein

Properties

COMPARTMENT: extracellular compartment SUBUNITS: glycoprotein hormone alpha 2 MOTIF: signal sequence {1-23} cysteine residue {C31} MODIFICATION: cysteine residue {C89} N-glycosylation site {N37} cysteine residue {C48} MODIFICATION: cysteine residue {C103} cysteine residue {C57} MODIFICATION: cysteine residue {C119} cysteine residue {C61} MODIFICATION: cysteine residue {C121} N-glycosylation site {N81} cysteine residue {C89} MODIFICATION: cysteine residue {C31} cysteine residue {C103} MODIFICATION: cysteine residue {C48} cysteine residue {C119} MODIFICATION: cysteine residue {C57} cysteine residue {C121} MODIFICATION: cysteine residue {C61} glycoprotein hormone beta 5 MOTIF: signal sequence {1-24} cysteine residue {C36} MODIFICATION: cysteine residue {C84} cysteine residue {C50} MODIFICATION: cysteine residue {C99} cysteine residue {C60} MODIFICATION: cysteine residue {C115} cysteine residue {C64} MODIFICATION: cysteine residue {C117} cysteine residue {C84} MODIFICATION: cysteine residue {C36} N-glycosylation site {N87} cysteine residue {C99} MODIFICATION: cysteine residue {C50} cysteine residue {C115} MODIFICATION: cysteine residue {C60} cysteine residue {C117} MODIFICATION: cysteine residue {C64} cysteine residue {C120} MODIFICATION: cysteine residue {C127} cysteine residue {C127} MODIFICATION: cysteine residue {C120}

References

UniProt :accession Q96T91, Q86YW7

Components

glycoprotein hormone alpha 2 (thyrostimulin alpha subunit, GPHA2, GPA2, ZSIG51) glycoprotein hormone beta 5 (thyrostimulin beta subunit, GPHB5, GPB5, ZLUT1)