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triiodothyronine [T3] receptor or erbA proto-oncogene protein
c-erbA proto-oncogene protein or thyroid hormone receptor. Apparently 2 different genes differentially expressed in different tissues, each with at least 2 different splice forms. The receptor is not associated with hsp90, thus no cytoplasmic anchoring. It binds to DNA as heterodimer with RXR. The unoccupied receptor binds to its recognition sequence & inhibits transcription.
Interactions
molecular events
Related
COP9 signalosome complex subunit 2; SGN2; signalosome subunit 2; alien homolog; JAB1-containing signalosome subunit 2; thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15 (COPS2, CSN2, TRIP15)
retinoid X receptor (RXR)
triiodothyronine (T3, liothyronine, Cytomel)
Specific
thyroid hormone receptor alpha; T3 receptor-alpha; nuclear receptor subfamily 1 group A member 1; C-erbA-alpha; c-erbA-1; EAR-7; EAR7 (THRA, ERBA1, NR1A1, THRA1, THRA2)
thyroid hormone receptor beta; nuclear receptor subfamily 1 group A member 2 (THRB, ERBA2, NR1A2, THR1)
General
nuclear hormone receptor NR1 subfamily
phosphoprotein
proto oncogene protein
Properties
COMPARTMENT: cytoplasm
MOTIF: allosteric site
DNA-binding motif
MOTIF: kxffkr
NAME: kxffkr
FOR-BINDING-OF: calreticulin
FORM: kxffkr
Zinc finger
NAME: Zinc finger (2)
EFFECTOR-BOUND: Zn+2
ligand-binding site
FOR-BINDING-OF: triiodothyronine
phosphorylation site
References
- Beato M et al
Transcriptional control by nuclear receptors.
FASEB J 5:2044 1991
PMID: 2010057
Component-of
molecular complex