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thymopoietin alpha; lamina-associated polypeptide 2, isoform alpha; TP alpha; thymopoietin-related peptide isoform alpha; TPRP isoform alpha; contains: thymopoietin; TP; splenin; TP5 (TMPO, LAP2)
Function:
- may be involved in the structural organization of the nucleus & in the post-mitotic nuclear assembly
- may play a role, together with LMNA, in nuclear anchorage of RB1
- TP & TP5 may play a role in T-cell development & function
- TP5 is an immunomodulating pentapeptide
- phosphorylated in a mitose-specific manner
- interacts with LMNA, BANF1 & RB1 & with chromosomes
- associates with lamins at specific cell-cycle stages
Structure:
- the N-terminal part contains two structurally independent, non-interacting domains:
- LEM-like (also called LAP2-N or LEM-D)
- LEM-like binds DNA while
- LEM (also called LAP2-C or LEM-B).
- LEM interacts with BANF1
- the C-terminal domain forms a four-stranded coiled coil
- belongs to the LEM family
- contains 1 LEM domain
- contains 1 LEM-like domain
Compartment:
- nucleus. chromosome
- expressed diffusely throughout the nucleus
Alternative splicing:
- named isoforms=3; alpha, beta, gamma
- additional isoforms seem to exist
Expression:
- expressed in many tissues
- most abundant in adult thymus & fetal liver
Pathology:
- defects in TMPO are the cause of dilated cardiomyopathy type 1T
Pharmacology:
- TP5 is available under the names Timunox (Cilag), Sintomodulina (Italofarmaco) & Mepentil (Recordati)
- used in treatment of primary & secondary immune deficiencies, autoimmunity, infections & cancer
Properties
GENERAL: thymopoietin
SIZE: entity length = 694 aa
MW = 75 kD
COMPARTMENT: cell nucleus
FORM: thymopoietin alpha
MOTIF: LEM-like {5-48}
Linker {49-108}
MOTIF: Ser phosphorylation site {S66}
Ser phosphorylation site {S67}
Thr phosphorylation site {T74}
Ser phosphorylation site {S79}
LEM domain {109-153}
Thr phosphorylation site {T154}
Ser phosphorylation site {S156}
Ser phosphorylation site {S159}
Thr phosphorylation site {T160}
Thr phosphorylation site {T164}
Ser phosphorylation site {S168}
Ser phosphorylation site {S177}
Ser phosphorylation site {S180}
Ser phosphorylation site {S184}
nuclear translocation signal {190-196}
Ser phosphorylation site {S272}
Ser phosphorylation site {S310}
Ser phosphorylation site {S351}
Ser phosphorylation site {S370}
Ser phosphorylation site {S424}
coiled coil {558-657}
Database Correlations
OMIM correlations
MORBIDMAP 188380
UniProt P42166
PFAM correlations
Entrez Gene 7112
Kegg hsa:7112
References
UniProt :accession P42166