thrombospondin-1 (THBS1, TSP, TSP1)

Function: - adhesive glycoprotein - mediates cell-to-cell & cell-to-matrix interactions - binds heparin - may play a role in dentinogenesis &/or maintenance of dentin & dental pulp - ligand for CD36 mediating antiangiogenic properties - interacts (via the TSP type I repeats) with HRG - the interaction blocks the antiangiogenic effect of THBS1 with CD36 (putative) - can bind to fibrinogen, fibronectin, laminin, type 5 collagen & integrin alpha-V/beta-1, integrin alpha-V/beta-3 & integrin alpha-IIb/beta-3 - interacts (via the TSP type I repeats) with CD36; - the interaction conveys an antiangiogenic effect Structure: - homotrimer; disulfide-linked - belongs to the thrombospondin family - contains 3 EGF-like domains - contains 1 TSP C-terminal (TSPC) domain - contains 1 TSP N-terminal (TSPN) domain - contains 3 TSP type-1 domains - contains 8 TSP type-3 repeats - contains 1 VWFC domain

Properties

SIZE: MW = 129 kD entity length = 1170 aa COMPARTMENT: plasma MOTIF: binding site SITE: 19-232 FOR-BINDING-OF: heparin N-glycosylation site {N248} cysteine residue {C270} MODIFICATION: cysteine residue {C270} cysteine residue {C270} MODIFICATION: cysteine residue {C270} cysteine residue {C274} MODIFICATION: cysteine residue {C274} cysteine residue {C274} MODIFICATION: cysteine residue {C274} N-glycosylation site {N360} TSP1 module {379-430} TSP1 module {435-491} TSP1 module {492-548} EGF domain {549-587} MOTIF: cysteine residue {C551} MODIFICATION: cysteine residue {C562} cysteine residue {C556} MODIFICATION: cysteine residue {C572} cysteine residue {C562} MODIFICATION: cysteine residue {C551} cysteine residue {C572} MODIFICATION: cysteine residue {C556} cysteine residue {C575} MODIFICATION: cysteine residue {C586} cysteine residue {C586} MODIFICATION: cysteine residue {C575} EGF domain {588-645} MOTIF: cysteine residue {C592} MODIFICATION: cysteine residue {C608} cysteine residue {C599} MODIFICATION: cysteine residue {C617} cysteine residue {C608} MODIFICATION: cysteine residue {C592} cysteine residue {C617} MODIFICATION: cysteine residue {C599} cysteine residue {C620} MODIFICATION: cysteine residue {C644} cysteine residue {C644} MODIFICATION: cysteine residue {C620} EGF domain {646-690} MOTIF: cysteine residue {C650} MODIFICATION: cysteine residue {C663} cysteine residue {C657} MODIFICATION: cysteine residue {C676} cysteine residue {C663} MODIFICATION: cysteine residue {C650} cysteine residue {C676} MODIFICATION: cysteine residue {C657} cysteine residue {C678} MODIFICATION: cysteine residue {C689} cysteine residue {C689} MODIFICATION: cysteine residue {C678} N-glycosylation site {N708} thrombospondin type 3 module {723-758} thrombospondin type 3 module {759-781} thrombospondin type 3 module {782-817} thrombospondin type 3 module {818-840} thrombospondin type 3 module {841-878} thrombospondin type 3 module {879-914} thrombospondin type 3 module {915-950} N-glycosylation site {N1067} SECRETED-BY: platelet

Database Correlations

OMIM 188060 UniProt P07996 PFAM correlations Entrez Gene 7057 Kegg hsa:7057