Search
thyroid hormone receptor alpha; T3 receptor-alpha; nuclear receptor subfamily 1 group A member 1; C-erbA-alpha; c-erbA-1; EAR-7; EAR7 (THRA, ERBA1, NR1A1, THRA1, THRA2)
Function:
- nuclear hormone receptor
- high affinity receptor for triiodothyronine (T3)
- interacts with NCOA3 & NCOA6 coactivators, leading to a strong increase of transcription of target genes
- probably interacts with SFPQ.
- interacts with C1D (putative)
- interacts with AKAP13
Structure:
1) composed of three domains:
a) modulating N-terminal domain
b) DNA-binding domain
c) C-terminal steroid-binding domain
2) belongs to the nuclear hormone receptor family, NR1 subfamily
3) contains 1 nuclear receptor DNA-binding domain
Compartment: nucleus
Alternative splicing: named isoforms=4
Related
erbA1 proto-oncogene
Specific
T3 receptor alpha-1, c-erbA alpha-1 protein or EAR-7-1
T3 receptor alpha-2, c-erbA alpha-2 protein or EAR-7-2
General
DNA-binding protein
triiodothyronine [T3] receptor or erbA proto-oncogene protein
zinc finger protein
Properties
SIZE: entity length = 490 aa
MW = 55 kD
COMPARTMENT: cell nucleus
MOTIF: Modulating {1-52}
DNA-binding motif
SITE: 53-127
MOTIF: Zn finger C4-type
SITE: 53-73
EFFECTOR-BOUND: Zn+2
Zn finger C4-type
SITE: 91-115
EFFECTOR-BOUND: Zn+2
binding site
SITE: 190-370
FOR-BINDING-OF: ligand
Database Correlations
OMIM 190120
UniProt P10827
PFAM correlations
Entrez Gene 7067
Kegg hsa:7067
References
- OMIM :accession 190120
- UniProt :accession P10827