THO complex subunit 4; Tho4; Ally of AML-1 & LEF-1; transcriptional coactivator Aly/REF; bZIP-enhancing factor BEF (THOC4, ALY, BEF, ALYREF)

Function: 1) acts as chaperone 2) promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains 3) promotes transcriptional activation 4) mRNA processing & export 5) component of THO/TREX complex recruited to transcribed genes 6) travels with RNA polymerase during elongation 7) component of exon junction complex 8) remains associated with spliced mRNA 9) mRNA export & nonsense-mediated RNA decay 10) binds LEF1 & RUNX1, NFX1, NXF1, RBM8A 11) binds UL54 from Herpes simplex type 1 12) component of several complexes involved in mRNA processing & export a) component of THO/TREX complex b) component of exon junction complex c) component of mRNA splicing-dependent exon junction complex Structure: - homomultimer - contains 1 RRM domain (RNA recognition motif) Compartment: - nucleus - translocates to cytoplasm as part of exon junction complex bound to mRNA Pathology: - antibodies against THOC4 are found in sera of patients with systemic lupus erythematosus

General

chaperonin; chaperone protein subunit

Properties

SIZE: MW = 27 kD entity length = 256 aa COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: 1-1 EFFECTOR-BOUND: acetyl glycine-rich region {20-230} MOTIF: RRM {105-182}

Database Correlations

OMIM 604171 UniProt Q86V81 Pfam PF00076

References

UniProt :accession Q86V81