Search
thiosulfate sulfurtransferase KAT (TSTD1)
Function:
thiosulfate + cyanide = sulfite + thiocyanate
Structure: contains 1 rhodanese domain
Compartment:
- cytoplasm, perinuclear region
- localized around the nuclear membranes
Alternative splicing: named isoforms=4
Expression:
- expressed in kidney, liver & skeletal muscle > heart, colon, thymus, spleen, placenta, lung > brain, small intestine, peripheral blood leukocytes
Pathology:
- possible role in tumorgenesis
- expressed at high levels in the breast carcinoma cell lines MCF-7 & MDA-MB-468 & at a lower level in the breast carcinoma cell line MDA-MB-231, the colon carcinoma cell line LoVo & the lung carcinoma cell line A549
- no expression in the cell lines EFO27 & HeLa, or the normal breast tissue cell lines MCF-10A & H184A1
- detected in invasive ductal carcinoma, but not in the adjacent tissues
General
transferase
Properties
SIZE: MW = 13 kD
entity length = 115 aa
COMPARTMENT: cytoplasm
nuclear membrane
MOTIF: Rhodanese {17-115}
MOTIF: cysteine residue {C79}
Database Correlations
UniProt Q8NFU3
Pfam PF00581
ENZYME 2.8.1.1
References
UniProt :accession Q8NFU3