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thiamine (vitamin B1) deficiency

Etiology: 1) beriberi 4) bariatric surgery [2,3] Clinical manifestations: 1) ophthalmoplegia [2] - ocular bobbing on primary gaze - no ocular bobbing on horizontal gaze [8] 2) foot drop [2] 3) paresthesia [2] 4) thiamine-responsive megaloblastic anemia syndrome* * relative deficiency Laboratory: - laboratory excepting contributions from alcoholism generally normal Radiology: - see Wernicke's encephalopathy Complications: 1) Korsakoff's syndrome 2) Wernicke's syndrome

Related

Korsakoff's syndrome (amnesic psychosis) thiamine-responsive megaloblastic anemia syndrome (Rodgers syndrome) Wernicke's syndrome (Wernicke's encephalopathy)

Specific

beriberi

General

vitamin B deficiency

References

  1. Stedman's Medical Dictionary 27th ed, Williams & Wilkins, Baltimore, 1999
  2. Medical Knowledge Self Assessment Program (MKSAP) 16 American College of Physicians, Philadelphia 2012 - Medical Knowledge Self Assessment Program (MKSAP) 19 Board Basics. An Enhancement to MKSAP19. American College of Physicians, Philadelphia 2022
  3. Aasheim ET. Wernicke encephalopathy after bariatric surgery: a systematic review. Ann Surg. 2008 Nov;248(5):714-20 PMID: 18948797
  4. Geriatric Review Syllabus, 8th edition (GRS8) Durso SC and Sullivan GN (eds) American Geriatrics Society, 2013 - Geriatric Review Syllabus, 11th edition (GRS11) Harper GM, Lyons WL, Potter JF (eds) American Geriatrics Society, 2022
  5. Vognar L, Stoukides J. The role of low plasma thiamin levels in cognitively impaired elderly patients presenting with acute behavioral disturbances. J Am Geriatr Soc. 2009 Nov;57(11):2166-8. PMID: 20121971
  6. Attaluri P, Castillo A, Edress H, et al. Thiamine deficiency: an important consideration in critically ill patients. Am J Med Sci. 2018:356(4):382-390 PMID: 30146080 https://www.amjmedsci.org/article/S0002-9629(18)30227-1/fulltext
  7. Chandrakumar A, Bhardwaj A, Jong GW. Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis. J Basic Clin Physiol Pharmacol. 2018:30(2):153-162 PMID: 30281514 https://www.degruyter.com/document/doi/10.1515/jbcpp-2018-0075/html
  8. NEJM Knowledge+