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thiamine (vitamin B1, Betalin)
Tradename: Betalin.
Indications:
1) thiamine deficiency
2) beriberi
3) Wernicke's encephalopathy
4) prevention of Wernicke'e encephalopathy in patients with alcoholism brought to hospital with altered mental status
5) cataracts prophylaxis [3]
6) septic shock [4]
Dosage:
1) RDA: male: 1.2-1.5 mg; female: 1.1 mg
- dietary intake for minimal risk of cognitive decline among older Chinese is 0.60-1.00 mg/day with inflection point at 0.68 mg/day [5]
- association between thiamine intake & cognitive decline strongest in elderly with hypertension, obesity & non-smokers [5]
2) wet berberi & myocardial failure: 10-20 mg IV TID
3) beriberi 10-20 mg IM TID for 2 weeks
4) prevention of Wernicke'e encephalopathy in alcoholics: 100 mg IV/IM
5) septic shock: 500 mg every 8 hours for 72 hours [4]
Injection: 100 mg/mL (1 mL)
Tablets: 50 mg, 100 mg.
Adverse effects:
- uncommon (< 1%)
- allergic reactions & anaphylaxis
- feelings of warmth
- pruritus
- paresthesias
- rash
- angioedema
- nausea
- cardiovascular collapse
Laboratory:
- thiamine in blood
- thiamine in serum/plasma
- thiamine in erythrocytes
- thiamine in urine
Interactions
molecular events
Related
thiamine (vitamin B1) deficiency
thiamine in body fluid
thiamine in erythrocytes
thiamine in serum/plasma/blood
thiamine in urine
Specific
benphothiamine; benfothiamine; S-Benzoylthiamine O-monophosphate (Biotamin, Berdi)
thiamine pyrophosphate
thiamine triphosphate
General
B vitamin
Properties
MISC-INFO: elimination route KIDNEY
pregnancy-category A
safety in lactation ?
Database Correlations
PUBCHEM correlations
Kegg map/map00730
References
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
- Jacques PF, Taylor A, Moeller S
Long-term nutrient intake and 5-year change in nuclear lens
opacification,
Arch Ophthalmol. 2005 Apr;123(4):517-26.
PMID: 15824226
- Woolum JA, Abner EL, Kelly A et al.
Effect of thiamine administration on lactate clearance and
mortality in patients with septic shock.
Crit Care Med 2018 Jul 18;
PMID: 30028362
https://insights.ovid.com/crossref?an=00003246-900000000-96192
- Liu C, Meng Q, Wei Y et al
J-shaped association between dietary thiamine intake and the risk of
cognitive decline in cognitively healthy, older Chinese individuals.
Gen Psychiatr. 2024 Feb 20;37(1):e101311.
PMID: 38390237 PMCID: PMC10882293 Free PMC Article
- Department of Veterans Affairs, VA National Formulary
Component-of
alpha tocopherol/ascorbate/beta carotene/calcium carbonate/cholecalciferol/cobalamin/docosahexaenoate/folic acid/magnesium oxide/nicotinamide/pyridoxine/riboflavin/thiamine/zinc oxide
alpha tocopherol/ascorbate/beta carotene/calcium carbonate/cholecalciferol/cobalamin/ferrous fumarate/folic acid/nicotinamide/pantothenate/pyridoxine/riboflavin/sodium docusate/thiamine/zinc oxide
alpha tocopherol/ascorbate/beta carotene/calcium carbonate/cholecalciferol/cobalamin/folic acid/magnesium oxide/nicotinamide/pyridoxine/riboflavin/thiamine/zinc oxide
alpha tocopherol/ascorbate/biotin/biotin/cobalamin/ergocalciferol/folic acid/multivitamin/nicotinamide/panthenol/pyridoxine/riboflavin/thiamine/vitamin a/vitamin k
alpha tocopherol/ascorbate/biotin/cholecalciferol/cobalamin/folic acid/nicotinamide/panthenol/pyridoxine/riboflavin/thiamine/vitamin a/vitamin k
alpha tocopherol/ascorbate/calcium carbonate/carbonyl iron/cholecalciferol/cobalamin/cupric oxide/folic acid/magnesium oxide/nicotinamide/pyridoxine/riboflavin/sodium docusate/thiamine/zinc oxide
alpha tocopherol/ascorbate/calcium citrate/carbonyl iron/cholecalciferol/docosahexaenoate/folic acid/nicotinamide/potassium iodide/pyridoxine/riboflavin/sodium docusate/thiamine/zinc oxide
alpha tocopherol/ascorbate/calcium citrate/carbonyl iron/cholecalciferol/folic acid/nicotinamide/potassium iodide/pyridoxine/riboflavin/sodium docusate/thiamine/zinc oxide
alpha tocopherol/ascorbate/carbonyl iron/cholecalciferol/cobalamin/folic acid/nicotinamide/pyridoxine/riboflavin/thiamine
alpha tocopheryl acetate/ascorbate/beta carotene/cobalamin/ergocalciferol/folic acid/nicotinic acid/pantothenate/pyridoxine/retinol/riboflavin/thiamine
alpha tocopheryl acetate/ascorbate/calcium carbonate/cobalamin/copper sulfate/ferrous fumarate/folic acid/magnesium oxide/nicotinamide/potassium iodide/pyridoxine/retinol/riboflavin/thiamine/vitamin d/zinc sulfate
alpha tocopheryl acetate/ascorbate/cholecalciferol/cobalamin/nicotinamide/pyridoxine/riboflavin/thiamine/vitamin a
ascorbate/beta carotene/calcium carbonate/carbonyl iron/cholecalciferol/cobalamin/folic acid/magnesium oxide/nicotinamide/pyridoxine/riboflavin/sodium docusate/thiamine/zinc oxide
ascorbate/bioflavonoid/choline bitartrate/cobalamin/inositol/nicotinamide/pantothenate/pyridoxine/riboflavin/thiamine
ascorbate/biotin/calcium carbonate/cobalamin/dextran/folic acid/iron dextran/nicotinic acid/pantothenate/pyridoxine/riboflavin/thiamine
ascorbate/biotin/calcium carbonate/cobalamin/ferrous fumarate/folic acid/magnesium oxide/nicotinamide/pantothenate/pyridoxine/riboflavin/thiamine/vitamin a/vitamin e/zinc oxide
ascorbate/biotin/calcium carbonate/cobalamin/ferrous fumarate/folic acid/magnesium oxide/nicotinamide/pantothenate/pyridoxine/riboflavin/thiamine/vitamin a/vitamin e/zinc/zinc oxide
ascorbate/biotin/cholecalciferol/cobalamin/folic acid/nicotinic acid/pantothenate/pyridoxine/riboflavin/thiamine
ascorbate/biotin/cobalamin/copper sulfate/ferrous fumarate/folic acid/magnesium sulfate/manganese sulfate/nicotinic acid/pantothenate/polysaccharide iron complex/pyridoxine/riboflavin/thiamine/zinc sulfate
ascorbate/biotin/cobalamin/folic acid/nicotinamide/pantothenate/pyridoxine/riboflavin/thiamine
ascorbate/biotin/cobalamin/folic acid/nicotinic acid/pantothenate/pyridoxine/riboflavin/thiamine
ascorbate/biotin/ferrous fumarate/folic acid/iron/methylcobalamin/nicotinamide/pantothenate/pyridoxine/riboflavin/thiamine
ascorbate/biotin/folic acid/methylcobalamin/nicotinamide/pantothenate/pyridoxine/riboflavin/thiamine
ascorbate/biotin/folic acid/methylcobalamin/nicotinamide/pantothenate/pyridoxine/riboflavin/thiamine/zinc citrate
ascorbate/calcium carbonate/cholecalciferol/choline bitartrate/cobalamin/docosahexaenoate/eicosapentaenoate/ferrous fumarate/folic acid/nicotinic acid/potassium iodide/pyridoxine/riboflavin/thiamine/vitamin e/zinc oxide
ascorbate/cholecalciferol/cobalamin/folic acid/magnesium oxide/nicotinic acid/polysaccharide iron complex/potassium iodide/pyridoxine/riboflavin/thiamine/vitamin a/vitamin e/zinc oxide
ascorbate/cholecalciferol/cobalamin/nicotinic acid/pyridoxine/riboflavin/sodium fluoride/thiamine/vitamin a/vitamin e
ascorbate/cobalamin/copper sulfate/ferrous fumarate/folic acid/magnesium sulfate/manganese sulfate/nicotinamide/pantothenate/polysaccharide iron complex/pyridoxine/riboflavin/thiamine/zinc sulfate
ascorbate/cobalamin/copper sulfate/ferrous fumarate/folic acid/magnesium sulfate/manganese sulfate/nicotinamide/pantothenate/pyridoxine/riboflavin/thiamine/zinc sulfate
ascorbate/cobalamin/copper sulfate/ferrous fumarate/folic acid/manganese sulfate/nicotinamide/pantothenate/polysaccharide iron complex/pyridoxine/riboflavin/thiamine/zinc sulfate
ascorbate/cobalamin/copper/copper sulfate/ferrous fumarate/folic acid/magnesium sulfate/manganese/manganese sulfate/nicotinamide/pantothenate/pyridoxine/riboflavin/thiamine/zinc sulfate
ascorbate/cobalamin/folic acid/nicotinic acid/pyridoxine/riboflavin/sodium fluoride/thiamine/vitamin a/vitamin d/vitamin e
ascorbate/cobalamin/nicotinic acid/pyridoxine/riboflavin/thiamine/vitamin a/vitamin d/vitamin e
ascorbate/ferrous sulfate/nicotinic acid/pyridoxine/riboflavin/thiamine/vitamin a/vitamin d/vitamin e
caffeine/cobalamin/ibuprofen/pyridoxine/riboflavin/thiamine
cobalamin/magnesium sulfate/manganese sulfate/nicotinamide/panthenol/pyridoxine/riboflavin/thiamine/zinc sulfate
cobalamin/magnesium sulfate/manganese/manganese sulfate/nicotinamide/panthenol/pyridoxine/riboflavin/thiamine/zinc sulfate
cobalamin/nicotinamide/panthenol/pyridoxine/riboflavin/thiamine
cobalamin/pyridoxine/thiamine
cobalamin/thiamine
Herbal Rescue
Nephro-Vite (vitamin B & C)
nicotinamide/panthenol/pyridoxine/riboflavin/thiamine
nicotinamide/pyridoxine/riboflavin/thiamine