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thiabendazole (Mintezol)

Tradename: Mintezol. Indications: - treatment of hookworm, pinworm, roundworm, threadworm, whipworm, ascarids - active against most intestinal nematodes - trichinosis, uncinariasis, strongyloidiasis, trichuriasis, trichostrongyliasis, toxocariasis, cutaneous larva migrans [4] Dosage: 1) take with meals 2) 22 mg/kg up to 1500 mg PO BID. 3) > 68 kg: 1.5 g PO BID for 2 days 4) < 68 kg 1.0 g PO BID for 2 days Tabs: 500 mg. Suspension: 500 mg/5 mL. Pharmacokinetics: 1) rapidly absorbed 2) metabolized by the liver 3) 90% eliminated in the urine 4) most is eliminated from the plasma in 8 hours Adverse effects: - Frequent: - anorexia, nausea/ vomiting, dizziness - Infrequent: - diarrhea, drowsiness, fatigue, headache fever, hallucinations, rashes, erythema multiforme, Stevens-Johnson syndrome - Rare: - angioneurotic edema, shock, tinnitus, convulsions, intrahepatic cholestasis - Others [3]: - dry mouth, dry eyes Up to 1/3 of patients administered thiabendazole are incapacitated for several hours by one or more symptoms urine may exhibit a distinctive odor, much like asparagus does in some individuals Mechanism of action: - complete helminth larvicidal activity occurs in vitro at a concentration of 10 pg/mL - this potency, combined with the absence of activity against other micro-organisms & the relatively low mammalian toxicity, suggest interference with metabolic pathway(s) intrinsic to & essential for helminth development [1] - it is suggested [3] that thiabendazoles interferes with helminth- specific fumarate reductase - unlike mebendazole, thiabendazole is absorbed systemically & is effective against helminths that undergo systemic migration

Interactions

drug interactions

General

antihelmintic benzimidazole

Properties

MISC-INFO: elimination route FECES pregnancy-category C safety in lactation ?

Database Correlations

PUBCHEM correlations

References

  1. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1990. pg 970
  2. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  3. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  4. Deprecated Reference

Component-of

dexamethasone/neomycin/thiabendazole