thrombospondin-2 (THBS2, TSP2)

Function: - adhesive glycoprotein - mediates cell-to-cell & cell-to-matrix interactions - ligand for CD36 mediating antiangiogenic properties - interacts (via the TSP type I repeats) with CD36 - the interaction conveys an antiangiogenic effect - interacts (via the TSP type I repeats) with HRG - the interaction blocks the antiangiogenic effect of THBS2 with CD36 (putative) - can bind to fibrinogen, fibronectin, laminin & type 5 collagen Structure: - homotrimer; disulfide-linked - belongs to the thrombospondin family - contains 3 EGF-like domains - contains 1 TSP C-terminal (TSPC) domain - contains 1 TSP N-terminal (TSPN) domain - contains 3 TSP type-1 domains - contains 8 TSP type-3 repeats - contains 1 VWFC domain Expression: - high expression in invertebral disk tissue Pathology: - polymorphisms in THBS2 may be a cause of susceptibility to lumbar disc herniation

Properties

SIZE: MW = 130 kD entity length = 1172 aa COMPARTMENT: plasma MOTIF: binding site SITE: 19-232 FOR-BINDING-OF: heparin N-glycosylation site {N151} cysteine residue {C266} MODIFICATION: cysteine residue {C266} cysteine residue {C266} MODIFICATION: cysteine residue {C266} cysteine residue {C270} MODIFICATION: cysteine residue {C270} cysteine residue {C270} MODIFICATION: cysteine residue {C270} N-glycosylation site {N316} N-glycosylation site {N330} TSP1 module {381-432} TSP1 module {437-493} MOTIF: N-glycosylation site {N457} TSP1 module {494-550} EGF domain {549-589} MOTIF: cysteine residue {C553} MODIFICATION: cysteine residue {C564} cysteine residue {C558} MODIFICATION: cysteine residue {C574} cysteine residue {C564} MODIFICATION: cysteine residue {C553} cysteine residue {C574} MODIFICATION: cysteine residue {C558} cysteine residue {C577} MODIFICATION: cysteine residue {C588} N-glycosylation site {N584} cysteine residue {C588} MODIFICATION: cysteine residue {C577} EGF domain {590-647} MOTIF: cysteine residue {C594} MODIFICATION: cysteine residue {C610} cysteine residue {C601} MODIFICATION: cysteine residue {C619} cysteine residue {C610} MODIFICATION: cysteine residue {C594} cysteine residue {C619} MODIFICATION: cysteine residue {C601} cysteine residue {C622} MODIFICATION: cysteine residue {C646} cysteine residue {C646} MODIFICATION: cysteine residue {C622} EGF domain {648-692} MOTIF: cysteine residue {C652} MODIFICATION: cysteine residue {C665} cysteine residue {C659} MODIFICATION: cysteine residue {C678} cysteine residue {C665} MODIFICATION: cysteine residue {C652} cysteine residue {C678} MODIFICATION: cysteine residue {C659} cysteine residue {C680} MODIFICATION: cysteine residue {C691} cysteine residue {C691} MODIFICATION: cysteine residue {C680} N-glycosylation site {N710} thrombospondin type 3 module {725-760} thrombospondin type 3 module {761-783} thrombospondin type 3 module {784-819} thrombospondin type 3 module {820-842} thrombospondin type 3 module {843-880} thrombospondin type 3 module {881-916} thrombospondin type 3 module {917-952} N-glycosylation site {N1069} SECRETED-BY: platelet

Database Correlations

OMIM correlations MORBIDMAP 188061 UniProt P35442 PFAM correlations Entrez Gene 7058 Kegg hsa:7058