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T helper 2 (Th2) cell

Function: Production of cytokines: 1) IL-4 2) IL-5 3) IL-9 in addition to GM-CSF, IL-2, IL-3, IL-10, IL-13 produced by both Th1 & Th2 cells. Additional functions: 1) assist in antibody production for the humoral response including IgE 2) mast cell proliferation 3) expression of vascular cell adhesion protein-1 (VCAM-1) 4) enhance growth & differentiation of B-cells & eosinophils 5) immune response to parasites Pathology: Present in mucosal tissue of patients with allergic respiratory disease, including asthma.

Related

granulocyte-macrophage colony-stimulating factor; GM-CSF; colony-stimulating factor 2; molgramostin; sargramostim (CSF2, GMCSF) immunoglobulin-E (IgE) interleukin-10; IL-10; cytokine synthesis inhibitory factor; CSIF (IL10) interleukin-13 (IL13, IL-13, NC30) interleukin-2; IL-2; T-cell growth factor; TCGF (IL2) interleukin-3; erythrocyte burst-promoting factor; hematopoietic growth factor; mast-cell colony-stimulating factor; multipotential colony-stimulating factor; colony-stimulating factor-2 alpha; mast cell growth factor; P-cell stimulating factor (IL3, IL-3) mast cell vascular cell adhesion protein 1; V-CAM 1; INCAM-100; CD106 (VCAM1, L1CAM)

General

helper T cell (T4 lymphocyte, CD4+)

References

  1. Scott Science 260:496 1993
  2. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
  3. Journal Watch 22(4):31, 2002