homeobox protein TGIF2; 5'-TG-3'-interacting factor 2; TGF-beta-induced transcription factor 2; TGFB-induced factor 2 (TGIF2)

Function: - transcriptional repressor - probably represses transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins - probably represses transcription via the recruitment of histone deacetylase proteins - the C-terminal part is phosphorylated in response to EGF signaling by the Ras/MAPK pathway - interacts with the transcriptional modulator SMAD3 & the histone deacetylase HDAC1 Structure: - belongs to the TALE/TGIF homeobox family - contains 1 homeobox DNA-binding domain Compartment: - nucleus - excluded from nucleoli Expression: - widely expressed - highly expressed in heart, kidney & testis - weakly expressed in brain & prostate Pahtology: - TGIF2 is amplified & overexpressed in several ovarian cancer cell lines

General

homeobox protein phosphoprotein transcriptional silencer (transcriptional repressor)

Properties

SIZE: entity length = 237 aa MW = 26 kD COMPARTMENT: cell nucleus MOTIF: homeodomain SITE: 16-79 Repressive function {103-237} MOTIF: Thr phosphorylation site {T182} Thr phosphorylation site {T186}

Database Correlations

OMIM 607294 UniProt Q9GZN2 Pfam PF05920 Entrez Gene 60436 Kegg hsa:60436

References

UniProt :accession Q9GZN2