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transcription factor IIIC (TFIIIC)
Function:
- the TFIIIC complex has two activities, C1 & C2
- the TFIIIC2 activity complex is only required for transcription of the 'classical' RNA polymerase 3 genes
- the TFIIIC1 activity complex is required for transcription of all RNA polymerase 3 genes
Structure:
- the TFIIIC1 activity complex is composed at least of BDP1
Interactions
molecular events
General
general transcription factor (basal transcription factor, transcription initiation factor)
multisubunit protein
phosphoprotein
Properties
COMPARTMENT: cell nucleus
MOTIF: phosphorylation site
SUBUNITS: general transcription factor 3C polypeptide 1
COMPARTMENT: cell nucleus
MOTIF: acidic region {343-351}
MOTIF: acidic residue (SEVERAL)
Ser phosphorylation site {S739}
Ser phosphorylation site {S751}
Thr phosphorylation site {T774}
Ser phosphorylation site {S1062}
Thr phosphorylation site {T1064}
Ser phosphorylation site {S1068}
lysine-rich region {1205-1233}
MOTIF: lysine residue (SEVERAL)
Ser phosphorylation site {S1611}
acidic region {1613-1624}
MOTIF: acidic residue (SEVERAL)
Ser phosphorylation site {S1632}
Ser phosphorylation site {S1653}
Ser phosphorylation site {S1856}
Ser phosphorylation site {S1865}
Ser phosphorylation site {S1868}
Ser phosphorylation site {S1969}
general transcription factor 3C polypeptide 2
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S165}
Ser phosphorylation site {S167}
Ser phosphorylation site {S220}
WD repeat {461-517}
WD repeat {548-589}
WD repeat {607-647}
WD repeat {828-870}
Ser phosphorylation site {S893}
Thr phosphorylation site {T895}
general transcription factor 3C polypeptide 3
COMPARTMENT: cell nucleus
MOTIF: glutamate-rich region {92-114}
MOTIF: glutamate residue (SEVERAL)
tetratricopeptide repeat {149-182}
tetratricopeptide repeat {183-216}
tetratricopeptide repeat {217-250}
tetratricopeptide repeat {252-284}
tetratricopeptide repeat {290-323}
tetratricopeptide repeat {326-361}
tetratricopeptide repeat {421-454}
tetratricopeptide repeat {456-489}
tetratricopeptide repeat {491-523}
tetratricopeptide repeat {733-766}
tetratricopeptide repeat {811-844}
general transcription factor 3C polypeptide 4
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S611}
general transcription factor 3C polypeptide 5
COMPARTMENT: cell nucleus
MOTIF: glutamate-rich region {478-514}
MOTIF: glutamate residue {486-499} (12)
References
- UniProt :accession A6H8Y1
- UniProt :accession Q12789
- UniProt :accession Q8WUA4
- UniProt :accession Q9Y5Q9
- UniProt :accession Q9UKN8
- UniProt :accession Q9Y5Q8
Components
general transcription factor 3C polypeptide 1; TF3C-alpha; TFIIIC box B-binding subunit; transcription factor IIIC 220 kD subunit; TFIIIC 220 kD subunit; TFIIIC220; transcription factor IIIC subunit alpha (GTF3C1)
general transcription factor 3C polypeptide 2; transcription factor IIIC-beta subunit; TF3C-beta; TFIIIC 110 kD subunit; TFIIIC110 (GTF3C2, KIAA0011)
general transcription factor 3C polypeptide 3; transcription factor IIIC-gamma subunit; TF3C-gamma; TFIIIC 102 kD subunit; TFIIIC102 (GTF3C3)
general transcription factor 3C polypeptide 4; transcription factor IIIC-delta subunit; TF3C-delta; TFIIIC 90 kD subunit; TFIIIC90 (GTF3C4)
general transcription factor 3C polypeptide 5; transcription factor IIIC-epsilon subunit; TF3C-epsilon; TFIIIC 63 kD subunit; TFIIIC63 (GTF3C5)
TFIIIC subcomplex TFIIIC2