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transcription factor EB (TFEB)
Function:
- probable transcription factor
- binds to the USF/MLTF site & probably recognizes E-box sequences in the heavy-chain immunoglobulin enhancer
- efficient DNA binding requires dimerization with another bHLH protein
Structure:
- belongs to the MiT/TFE family
- contains 1 basic helix-loop-helix (bHLH) domain
Compartment: nucleus
Alternative splicing: named isoforms=2
General
basic helix loop helix (bHLH) family transcription factor
phosphoprotein
Properties
SIZE: entity length = 476 aa
MW = 53 kD
COMPARTMENT: cell nucleus
MOTIF: glutamine-rich region {10-44}
MOTIF: glutamine residue (SEVERAL)
glutamine-rich region {35-44}
MOTIF: glutamine residue (SEVERAL)
transcriptional activation domain
SITE: 156-165
DNA-binding motif
SITE: 233-248
helix-loop-helix
NAME: helix-loop-helix
SITE: 249-289
FOR-BINDING-VIA: helix-loop-helix
leucine zipper
SITE: 298-319
FOR-BINDING-VIA: leucine zipper
proline-rich region
SITE: 366-414
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S467}
Database Correlations
OMIM 600744
UniProt P19484
Pfam PF00010
Entrez Gene 7942
Kegg hsa:7942
References
- Ross CA, McInnis MG, Margolis RL, Li SH.
Genes with triplet repeats: candidate mediators of
neuropsychiatric disorders.
Trends Neurosci. 1993 Jul;16(7):254-60. Review.
PMID: 7689767
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/TFEBID531.html
- UniProt :accession P19484