mitochondrial dimethyladenosine transferase 2 (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2, mitochondrial 12S rRNA dimethylase 2, mitochondrial transcription factor B2, mtTFB2, h-mtTFB2, h-mtTFB, hTFB2M, hepatitis C virus NS5A-transactivated protein 5, HCV NS5A-transactivated protein 5, TFB2M, NS5ATP5)

Function: 1) S-adenosyl-L-methionine-dependent methyltransferase 2) specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop 3) required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT & TFAM 4) stimulates transcription independently of methyltransferase activity 5) compared to TFB1M - activates transcription of mitochondrial DNA more efficiently - has less methyltransferase activity 6) interacts with mitochondrial RNA polymerase POLRMT. 7) interacts with TFAM Structure: - belongs to the rRNA adenine N(6)-methyltransferase family. KsgA subfamily Compartment: mitochondrion Expression: - ubiquitously expressed - induced by the nuclear respiratory factors NRF1 & NRF2/GABPB2 & PGC-1 coactivators

General

methyltransferase mitochondrial protein

Properties

SIZE: MW = 45 kD entity length = 396 aa COMPARTMENT: mitochondria MOTIF: active site

Database Correlations

OMIM 607055 UniProt Q9H5Q4 Pfam PF00398

References

UniProt :accession Q9H5Q4