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transcription factor AP-2 gamma; AP2-gamma; activating enhancer-binding protein 2 gamma; transcription factor ERF-1 (TFAP2C)
Function:
- sequence-specific DNA-binding protein
- interacts with inducible viral & cellular enhancer elements to regulate transcription of selected genes
- AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' & activate genes involved in a large spectrum of biological functions
- AP-2 factors also suppress a number of genes including MCAM/MUC18, C/EBP alpha & MYC
- binds DNA as a dimer
- can form homodimers or heterodimers with other AP-2 family members (putative)
- interacts with WWOX
- interacts with CITED4
- interacts with UBE2I
- sumoylated on Lys-10; which inhibits transcriptional activity
Structure:
- WW-binding motif mediates interaction with WWOX
- belongs to the AP-2 family
Compartment: nucleus (probable)
Expression: during retinoic acid-mediated differentiation
General
activating protein 2 (AP2)
oligomerizing protein
phosphoprotein
Properties
SIZE: entity length = 450 aa
MW = 49 kD
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 30-119
MOTIF: proline residue (SEVERAL)
WW-binding {59-64}
Ser phosphorylation site {S252}
H-S-H (helix-span-helix), dimerization {293-424}
Ser phosphorylation site {S434}
Database Correlations
OMIM 601602
UniProt Q92754
Pfam PF03299
Entrez Gene 7022
Kegg hsa:7022
References
- UniProt :accession Q92754
- Wikipedia; Note: activatin protein 2 entry
http://en.wikipedia.org/wiki/activating_protein_2