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transcription factor AP-2-alpha; AP2-alpha; AP-2 transcription factor; activating enhancer-binding protein 2-alpha; activator protein 2 (TFAP2A, AP2TF, TFAP2)

Function: - sequence-specific DNA-binding protein - interacts with inducible viral & cellular enhancer elements to regulate transcription of selected genes - AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' & activate genes involved in a large spectrum of biological functions - AP-2 also suppress a number of genes including MCAM/MUC18, C/EBP alpha & MYC - AP-2 alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle (putative) - binds DNA as a dimer - can form homodimers or heterodimers with other AP-2 family members - interacts with WWOX - interacts with CITED4. interacts with UBE2I - interacts with RALBP1 in a complex also containing EPN1 & NUMB during interphase & mitosis - sumoylated on Lys-10; which inhibits transcriptional activity (probable) - activity induced by PKC Structure: - WW-binding motif mediates interaction with WWOX - belongs to the AP-2 family Compartment: nucleus Alternative splicing: named isoforms=4 Pathology: - defects in TFAP2A are the cause of branchiooculofacial syndrome

General

activating protein 2 (AP2) phosphoprotein

Properties

SIZE: entity length = 437 aa MW = 48 kD COMPARTMENT: cell nucleus MOTIF: proline-rich region SITE: 29-117 MOTIF: proline residue (SEVERAL) WW-binding {57-62} Ser phosphorylation site {S225} Ser phosphorylation site {S239} H-S-H (helix-span-helix), dimerization {280-410}

Database Correlations

OMIM correlations MORBIDMAP 107580 UniProt P05549 Pfam PF03299 Entrez Gene 7020 Kegg hsa:7020

References

  1. Ruben SM, Dillon PJ, Schreck R, Henkel T, Chen CH, Maher M, Baeuerle PA, Rosen CA. Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-kappa B. Science. 1991 Oct 4;254(5028):11. PMID: 1925549 - Ruben SM, Dillon PJ, Schreck R, Henkel T, Chen CH, Maher M, Baeuerle PA, Rosen CA. Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-kappa B. Science. 1991 Mar 22;251(5000):1490-3. Erratum in: Science. 1991 Oct 4;254(5028):11. PMID: 2006423
  2. Alberts et al Molecular Biology of the Cell, 2nd ed. 1989, pg 566
  3. Wikipedia; Note: activatin protein 2 entry http://en.wikipedia.org/wiki/activating_protein_2
  4. UniProt :accession P05549