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tezosentan
Contraindications:
- no clinical benefit for acute heart failure
Dosage:
- 2.5 mg IV over 30 minutes, then 1 mg/hr IV for 24-72 hours
Adverse effects: hypotension
Mechanism of action:
- endothelin receptor antagonist
- inhibits endothelin receptor 1 & endothelin receptor 2
- signficant hemodynamic improvements with tezosentan did not translate to improved clinical outcomes [2]
Interactions
drug adverse effects of antihypertensive agents
General
endothelin receptor antagonist
References
- McMurray JJ et al, for the VERITAS Investigators
Effects of tesosentain on symptoms and clinical outcomes in
patients with acute heart failure: The VERITAS randomized
controlled trials.
JAMA 2007, 298:2009
PMID: 17986694
- McMurray JJV et al,
Effects of tezosentan on symptoms and clinical outcomes in
patients with acute heart failure: The VERTAS randomized
controlled trials.
JAMA 2007, 2009
PMID: 17986694