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testis-expressed protein 101 (scleroderma-associated autoantigen, cell surface receptor NYD-SP8, spermatogenesis-related gene protein, TEX101, SGRG, UNQ867/PRO1884)
Function:
- role in signal transduction
- promote protein tyrosine phosphorylation (putative)
- interacts with VAMP3
Structure:
- N-glycosylated
- contains 1 UPAR/Ly6 domain
Compartment: cell membrane, GPI-anchor
Alternative splicing: named isoforms=2
Expression:
- detected in testis & spermatogonia
- not detected in spermatocytes
- detected in blood leukocytes
Pathology:
- antibodies against TEX101 are present in sera from patients with scleroderma
General
glypiated protein
Properties
SIZE: MW = 27 kD
entity length = 249 aa
COMPARTMENT: plasma membrane
CELL-REGION: apical region
CELL: epithelial cell
MOTIF: signal sequence {1-25}
N-glycosylation site {N45}
N-glycosylation site {N159}
glycosyl phosphatidylinositol [GPI] membrane anchor {N222}
Database Correlations
UniProt Q9BY14
Pfam PF00021
References
UniProt :accession Q9BY14