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tetrahydrocannabinol; delta-9-tetrahydrocannabinol; THC

delta-9-Tetrahydrocannabinol (THC) is an active component of marijuana. Pharmacokinetics: - active metabolite 11-hydroxytetrahydrocannabinol - metabolized to 11-nor-9-carboxy-delta-9-tetrahydrocannabinol Adverse effects: - used during encoding impairs memory acquisition - used during retrieval associated with false recognition of words & images [3] - vitamin E acetate found in most of the tetrahydrocannabinol (THC) vaping products tested in patients with severe respiratory illness [4] - impairs driving [5] - dose-related dizziness & changes in thinking & perception with THC only but not THC-CBD combination Laboratory: - tetrahydrocannabinol in hair - tetrahydrocannabinol in blood - tetrahydrocannabinol in gastric fluid - tetrahydrocannabinol in meconium - tetrahydrocannabinol in serum/plasma - tetrahydrocannabinol in stool - tetrahydrocannabinol in urine* * delta-9-Tetrahydrocannabinol homologs may evade qualitative urine drug screen Comparative biology: - a chronic low dose of delta-9 tetrahydrocannabinol may restore CB1 receptor signaling in old mice [2] - potential effective strategy to treat age-related cognitive impairment [2]

Interactions

drug adverse effects of psychotropic agents

Related

cannabinoid in urine

Specific

11-hydroxytetrahydrocannabinol; 11-hydroxy delta-9-tetrahydrocannabinol 11-nor-9-carboxy-delta-9-tetrahydrocannabinol dronabinol (Marinol)

General

cannabinoid (spice, K2, AMB-FUBINACA)

Properties

Database Correlations

PUBCHEM correlations

References

  1. Hoyte CO et al. A characterization of synthetic cannabinoid exposures reported to the National Poison Data System in 2010. Ann Emerg Med 2012 Oct; 60:435. PMID: 22575211
  2. Bilkei-Gorzo A, Albayram O, Draffehn A et al A chronic low dose of delta-9 tetrahydrocannabinol (THC) restores cognitive function in old mice. Nat Med. 2017 May 8. doi: 10.1038/nm.4311. PMID: 28481360
  3. Doss MK, Weafer J, Gallo DA, de Wit H delta-9 Tetrahydrocannabinol at retrieval drives false recollection of neutral and emotional memories. Biol Psychiatry 2018 May 9; PMID: 29884456 https://www.biologicalpsychiatryjournal.com/article/S0006-3223(18)31477-X/fulltext
  4. FDA Safety Alert. Sept 6, 2019 Tetrahydrocannabinol (THC)-containing Vaping Products: Vaping Illnesses. https://www.fda.gov/safety/medwatch-safety-alerts-human-medical-products/tetrahydrocannabinol-thc-containing-vaping-products-vaping-illnesses
  5. George J Does Cannabidiol Impair Driving? - Driving tests suggest no, unless THC is added to the mix. MedPage Today December 1, 2020 https://www.medpagetoday.com/neurology/generalneurology/89956 Arkell TR, Vinckenbosch F, Kevin RC et al Effect of Cannabidiol and delta-9-Tetrahydrocannabinol on Driving Performance. A Randomized Clinical Trial. JAMA. 2020;324(21):2177-2186. Dec 1 PMID: 33258890 PMCID: PMC7709000 Free PMC article https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2020.21218
  6. Velayudhan L et al. Evaluation of THC-related neuropsychiatric symptoms among adults aged 50 years and older: A systematic review and metaregression analysis. JAMA Netw Open 2021 Feb 2; 4:e2035913 PMID: 33528550 PMCID: PMC7856542 Free PMC article https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2775736

Component-of

nabiximols (Sativex, Cannador)