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tetanus immune globulin (HyperTet, TIG, tetanus antitoxin)
Indications: passive immunity to tetanus
Contraindications:
Caution:
1) IV administration is contraindicated
2) never administer TIG & tetanus toxoid in the same syringe; both will be neutralized
pregnancy-category C
safety in lactation ?
Dosage:
1) post-exposure prophylaxis: 250 U IM once generally with tetanus toxoid if never immunized
2) treatment of tetanus: 3000-6000 U IM once
Injection: 250 units.
Pharmacokinetics: elimination: liver
Adverse effects:
1) common (> 10%)
- pain, tenderness & erythema at site of injection*
2) less common (1-10%)
- fever (mild), urticaria, angioedema, muscle stiffness, anaphylaxis
3) uncommon (< 1%)
- sensitization to repeated injections
* local tenderness & soreness of muscles may persist up to 3 days
Mechanism of action:
- contains tetanus antitoxin antibodies which neutralize exotoxin produced by Clostridium tetani
Related
tetanus
General
immune globulin (Gamastan, Gamimune N, Gammagard, Gammar, Sandoglobulin, Venoglobulin-I, Venoglobulin-S, ISG, Vivaglobulin, Gamunex, Privigen, Gammaplex, Flebogamma, Gammaked, Bivigam, Carimune, Hizentra)
antitoxin (passive immunizing agent, immune serum)
References
- Saunders Manual of Medical Practice, Rakel (ed), WB Saunders,
Philadelphia, 1996, pg 7
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998