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CXXC-type zinc finger protein 6; leukemia-associated protein with a CXXC domain (CXXC6, TET1, KIAA1676, LCX)
Function:
- fetal development of heart, lung & brain (putative)
Structure:
- contains 1 CXXC-type zinc finger
Compartment: nucleus
Expression:
- expressed in fetal heart, lung, brain, & in adult skeletal muscle, thymus, ovary
- not expressed in adult heart, lung or brain
Pathology:
- chromosomal translocation t(10;11)(q22;q23) of CXXC6 with MLL (5' MLL-CXXC6 3') is associated with acute leukemia (rare)
General
zinc finger protein
Properties
SIZE: MW = 235 kD
entity length = 2136 aa
COMPARTMENT: cell nucleus
MOTIF: Zinc finger
NAME: Zinc finger
SITE: 584-625
EFFECTOR-BOUND: Zn+2
coiled coil {2062-2091}
Database Correlations
OMIM 607790
UniProt Q8NFU7
Pfam PF02008
References
UniProt :accession Q8NFU7