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testosterone oral; testosterone undecanoate (Jatenzo)
Indications:
- hypogonadism
Contraindications:
- breast cancer
- known or suspected prostate cancer
* caution use in the elderly (insufficient safety data)
Dosage:
- start 237 mg BID (take with food)
- titrate to 150-396 mg BID*
* based on serum testosterone drawn 6 hours after the morning dose at least 7 days after starting treatment
Capsules: 158,, 198, & 237 mg
Adverse effects:
- hypertension
- increased risk of cardiovascular disease
- polycythemia
- diarrhea
- dyspepsia
- eructation
- peripheral edema
- nausea
- headache
- prostatic hypetrophy
* also see testosterone
Drug interactions:
- insulin: may reduce insulin requirements; monitor for hypoglycemia
- anticoagulants: may affect INR
- glococorticoids in combination may increase risk of edema
- drugs known to increase blood pressure
* also see testosterone
Interactions
drug adverse effects of androgens
General
testosterone (Delatestryl Testopel, Striant, Intrinsa, Xyosted)
References
- Swerdloff RS, Wang C, White WB, et al.
A new oral testosterone undecanoate formulation restores testosterone
to normal concentrations in hypogonadal men.
J Clin Endocrinol Metab 2020 Aug; 105:dgaa238.
PMID: 32382745 Free PMC article.
https://academic.oup.com/jcem/article/105/8/dgaa238/5834353
- HIGHLIGHTS OF PRESCRIBING INFORMATION
Jatezo (ttestosterone undecanoate)
https://www.jatenzo.com/assets/pdfs/jatenzo-pi.pdf